M'zaka zaposachedwa, pakhala chidwi chochulukirapo pazinthu zachilengedwe zomwe zingapangitse thanzi labwino komanso thanzi. Urolithin A ndi urolithin B ndi mitundu iwiri yachilengedwe yochokera ku ellagitannins yomwe imapezeka mu zipatso ndi mtedza wina. Zotsutsana ndi zotupa, antioxidant, ndi zomanga minofu zimawapangitsa kukhala zinthu zosangalatsa zolimbikitsa thanzi labwino. Ngakhale urolithin A ndi urolithin B ali ndi zofananira, amakhalanso ndi kusiyana kwakukulu.
Urolithin A ndi B ndi metabolites omwe amapangidwa mwachilengedwe mkati mwa thupi la munthu chifukwa cha kugayidwa kwa zigawo zina zazakudya, makamaka ellagitannins. Ellagitannins amapezeka mu zipatso zosiyanasiyana ndi mtedza, kuphatikizapo makangaza, sitiroberi, raspberries, mabulosi akuda, ndi walnuts. Komabe, ndi anthu ochepa okha omwe ali ndi mabakiteriya am'matumbo omwe amatha kusintha ellagitannins kukhala urolithin, zomwe zimapangitsa kuti milingo ya urolithin mwa anthu ikhale yosiyana kwambiri.
Kwa iwo omwe amavutika kukwaniritsa zosowa zawo za magnesium kudzera muzakudya zokha, ma magnesium owonjezera amatha kupindulitsa thanzi m'njira zingapo ndipo amabwera m'mitundu monga magnesium oxide, magnesium threonate, magnesium taurate, ndi magnesium glycinate. Komabe, tikulimbikitsidwa kukaonana ndi akatswiri azachipatala musanayambe kumwa mankhwala owonjezera kuti mupewe kuyanjana kapena zovuta zomwe zingachitike.
Urolithin A ndi molekyu yochuluka kwambiri mu banja la urolithin, ndipo katundu wake wa antioxidant ndi anti-inflammatory awerengedwa bwino. Kafukufuku wasonyeza kuti urolithin A imatha kusintha ntchito ya mitochondrial ndikuletsa kuwonongeka kwa minofu. Kuphatikiza apo, kafukufuku wasonyeza kuti urolithin A imatha kuletsa kuchuluka kwa ma cell ndikupangitsa kufa kwa maselo m'maselo osiyanasiyana a khansa.
Urolithin B wakopa chidwi cha ofufuza chifukwa cha kuthekera kwake kopititsa patsogolo thanzi lamatumbo komanso kuchepetsa kutupa. Kafukufuku akuwonetsa kuti urolithin B imatha kupititsa patsogolo kusiyanasiyana kwa tizilombo tating'onoting'ono ndikuchepetsa ma cytokines oyambitsa kutupa monga interleukin-6 ndi tumor necrosis factor alpha. Kuonjezera apo, urolithin B wapezeka kuti uli ndi mphamvu zoteteza ubongo, ndipo kafukufuku wosonyeza kuti angathandize kupewa matenda a neurodegenerative monga Parkinson's ndi Alzheimer's.
Ngakhale urolithin A ndi urolithin B ali ndi zofananira, ali ndi kusiyana kwakukulu. Mwachitsanzo, urolithin A yasonyezedwa kuti ndi yothandiza kwambiri ngati anti-inflammatory and antioxidant kusiyana ndi urolithin B. Urolithin B, kumbali ina, inapezeka kuti imakhala yothandiza kwambiri popewa mavuto okhudzana ndi kunenepa kwambiri, monga insulin resistance ndi adipocyte. kusiyana.
Njira zogwirira ntchito za urolithin A ndi urolithin B ndizosiyana. Urolithin A imayendetsa njira ya peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) njira, yomwe imagwira ntchito mu mitochondrial biogenesis, pamene urolithin B imawonjezera njira ya AMP-activated protein kinase (AMPK), yomwe imakhudzidwa ndi mphamvu ya homeostasis. Njirazi zimathandizira kuti pakhale thanzi labwino la mankhwalawa.
●Anti-kutupa katundu
Kutupa kosatha kumadziwika kuti kumathandizira ku matenda angapo. Urolithin A wawonetsedwa kuti ali ndi mphamvu zoletsa kutupa, zomwe zimachepetsa kupanga mamolekyu otupa. Poletsa kutupa, kungathandize kuthana ndi matenda osiyanasiyana monga nyamakazi, matenda amtima, ndi mitundu ina ya khansa.
●Thanzi la Minofu ndi Mphamvu
Pamene tikukalamba, kuwonongeka kwa minofu ya chigoba kumakhala vuto lalikulu. Urolithin A wapezeka kuti amalimbikitsa kukula kwa maselo a minofu ndikulimbikitsa kugwira ntchito kwa minofu, kulimbikitsa thanzi la minofu ndi mphamvu. Izi zimakhala ndi lonjezo kwa anthu omwe akufuna kusunga minofu ndikulimbana ndi kuchepa kwa minofu yokhudzana ndi ukalamba.
●Thanzi la Mitochondrial ndi Moyo Wautali
Urolithin A amawonetsa mphamvu pa mitochondria, yomwe nthawi zambiri imatchedwa mphamvu zama cell athu. Zimayambitsa njira yotchedwa mitophagy, yomwe imaphatikizapo kuchotsa mwa kusankha kwa mitochondria yowonongeka. Polimbikitsa ntchito ya mitochondrial yathanzi, urolithin A imatha kuthandizira kukhala ndi moyo wautali komanso kuteteza kuzinthu zokhudzana ndi ukalamba monga matenda a neurodegenerative.
●Antioxidant ntchito
Urolithin B ndi antioxidant wamphamvu yemwe amathandizira kuletsa ma free radicals owopsa m'thupi. Ma radicals aulere ndi mamolekyu omwe amatha kuyambitsa kuwonongeka kwa ma cell komanso kupsinjika kwa okosijeni, komwe kumakhudzidwa ndi matenda osiyanasiyana. Ntchito ya antioxidant ya Urolithin B imathandizira kuteteza maselo athu ku kuwonongeka kotereku ndipo amachepetsa chiopsezo cha matenda osatha.
●Gut Health ndi Microbiome Modulation
Matumbo athu amagwira ntchito yofunika kwambiri pa thanzi lathu lonse, ndipo urolithin B yatuluka ngati gawo lofunikira pakusunga matumbo athanzi a microbiome. Imalimbikitsa kukula kwa Beneficial mabakiteriya ndikulepheretsa kukula kwa mabakiteriya owopsa, motero kumapangitsa kuti chilengedwe chikhale choyenera. M'matumbo abwino kwambiri a microbiome amalumikizidwa ndi kugaya bwino, chitetezo chamthupi, komanso kukhala ndi thanzi labwino.
●Limbikitsani thanzi la minofu
Urolithin B yawonetsedwa kuti imathandizira mitochondrial autophagy, njira yama cell yomwe imathandiza kuchotsa mitochondria yowonongeka m'maselo. Izi zimathandiza kupititsa patsogolo thanzi labwino la minofu ndi ntchito, zomwe zimapangitsa kuti zikhale zowonjezera kwa iwo omwe akufuna kuti azichita bwino. Kafukufuku wina adapeza kuti urolithin B imathandizira kugwira ntchito kwa minofu ndi mphamvu mu mbewa ndi anthu.
Urolithins amapangidwa m'matupi athu tikamadya zakudya zina zomwe zili ndi ellagitannins. Zakudya zazikulu za ellagitannins ndi izi:
a) Makangaza
Makangaza ndi amodzi mwazakudya zolemera kwambiri za ellagitannins, zomwe zimasinthidwa kukhala urolithin A ndi urolithin B ndi mabakiteriya am'matumbo. Kudya zipatso za makangaza, madzi, kapena zowonjezera zimatha kukulitsa madyedwe anu azinthu zamphamvuzi, kupititsa patsogolo thanzi la ma cell komanso kukhala ndi zotsutsana ndi zotupa.
b) Zipatso
Zipatso zosiyanasiyana monga sitiroberi, raspberries, ndi mabulosi akuda zimakhala ndi ellagitannins yambiri. Kafukufuku wasonyeza kuti kudya zipatso zowoneka bwinozi kumalimbikitsa kupanga urolithin A ndi urolithin B m'matumbo. Kuonjezera zipatso muzakudya zanu kumangowonjezera kukoma komanso kumakupatsani mapindu azaumoyo kwanthawi yayitali.
c) Mtedza
Mtedza, makamaka walnuts ndi pecans, ndi magwero olemera a ellagitannins. Kuphatikiza apo, amadzaza ndi mafuta athanzi, fiber, ndi michere ina yofunika. Kuphatikizira mtedza muzakudya zanu zatsiku ndi tsiku sikumangopereka urolithin A ndi B komanso kumapereka maubwino ambiri azaumoyo kumtima, ubongo, komanso thanzi labwino.
d) Vinyo wakale wa thundu
Ngakhale zingadabwe, kumwa mowa pang'ono kwa vinyo wofiira wazaka za oak kungathandizenso kupanga urolithin. Zosakaniza zomwe zimapezeka m'migolo ya oak zomwe zimagwiritsidwa ntchito pokalamba vinyo zimatha kuchotsedwa panthawi ya ukalamba, ndikulowetsa vinyo ndi ellagitannins. Komabe, ndi bwino kukumbukira kuti kumwa mowa mopitirira muyeso kumakhala ndi zotsatirapo zoipa pa thanzi, choncho kusamalidwa bwino n’kofunika kwambiri.
e) Zomera za Ellagitannin
Pafupi ndi makangaza, zomera zina monga khungwa la oak, sitiroberi, ndi masamba a oak mwachibadwa zimakhala zambiri mu ellagitannins. Kuphatikizira zomerazi muzakudya zanu kungathandize kukulitsa milingo ya urolithin A ndi urolithin B m'thupi lanu, kuthandizira thanzi la ma cell ndikukulitsa thanzi lanu lonse.
Kuphatikizaurolithin A ndi B m'moyo wanu, njira imodzi yabwino ndiyo kudya zakudya zokhala ndi ellagitannins. Makangaza, sitiroberi, raspberries, ndi walnuts ndi magwero abwino kwambiri.
Komabe, ndikofunikira kuzindikira kuti zomwe zili mu ellagitannin zimasiyanasiyana mkati mwa chipatso chilichonse, ndipo si onse omwe ali ndi matumbo a microbiota omwe amatha kusintha ellagitannins kukhala urolithins. Chifukwa chake, anthu ena sangathe kupanga urolithin moyenera kuchokera kuzakudya izi. zowonjezera ndi njira ina yowonetsetsa kuti urolithin A ndi B akudya mokwanira.
Q: Kodi Urolithin A ndi Urolithin B amalimbikitsa bwanji thanzi la mitochondrial?
A: Urolithin A ndi Urolithin B amatsegula njira ya ma cell yotchedwa mitophagy, yomwe imakhala ndi udindo wochotsa mitochondria yowonongeka m'maselo. Polimbikitsa mitophagy, mankhwalawa amathandizira kukhala ndi mitochondrial yathanzi, yomwe ndiyofunikira pakupanga mphamvu komanso kugwira ntchito kwa ma cell.
Q: Kodi Urolithin A ndi Urolithin B angapezeke kudzera muzowonjezera?
A: Inde, zowonjezera za Urolithin A ndi Urolithin B zilipo pamsika. Komabe, ndikofunika kuzindikira kuti mphamvu ndi chitetezo cha zowonjezera izi zikhoza kusiyana. Ndikoyenera kukaonana ndi katswiri wazachipatala musanayambe zakudya zatsopano zowonjezera zakudya.
Chodzikanira: Nkhaniyi ndi yongofuna kudziwa zambiri ndipo siyenera kutengedwa ngati upangiri wachipatala. Nthawi zonse funsani akatswiri azachipatala musanagwiritse ntchito zowonjezera kapena kusintha dongosolo lanu lazaumoyo.
Nthawi yotumiza: Sep-13-2023
