Kuwulula Zomwe Zaposachedwa mu Zowonjezera za Alpha GPC za 2024

Choline Alfoscerate,amadziwikanso kuti Alpha-GPC, ndi chinthu chochokera ku lecithin ya zomera, koma si phospholipid, koma phospholipid yochokera ku Lipophilic fatty acid substances. Alpha-GPC ndi michere yambiri yomwe imapezeka m'maselo onse a mammalian. Chifukwa ndi hydrophilic kwambiri, imalowa mwachangu pambuyo pakamwa. GPC ndi kalambulabwalo wa acetylcholine (ACh) ndipo imakhala ndi lonjezo lalikulu pakusokonekera kwa choline.

GPC imawoloka chotchinga chamagazi-muubongo ndipo imapereka gwero la choline pa biosynthesis ya ACh ndi phosphatidylcholine. Phospholipids ndi acetylcholine, zikakwaniritsidwa pamlingo wabwino kwambiri, zimalimbikitsa chidziwitso, malingaliro ndi thanzi laubongo. Kuphatikiza apo, kuchuluka kwa Alpha-GPC ndi Ach kumatha kulimbikitsa machitidwe amthupi ndikuwongolera magwiridwe antchito. ACh imatenga nawo mbali pakudumpha kwa minofu ndipo ndiye neurotransmitter yayikulu yomwe imayang'anira kuyankhidwa kwa thupi kuchita masewera olimbitsa thupi.

Popeza kusuntha kwa minofu yonse kumagwirizana ndi kugwedezeka, ndipo kutsekemera kumagwirizana ndi ma cell a ACh omwe alipo, kukulitsa milingo ya ACh kumawonjezera magwiridwe antchito a minofu. Poyerekeza ndi ma precursors ena odziwika a choline, Alpha-GPC mosamala komanso moyenera imawonjezera kuchuluka kwa choline m'magazi ndi ubongo. Kafukufuku wambiri watsimikizira ubwino wosiyanasiyana wa Alpha-GPC ndipo adanena kuti kuwonjezera pakamwa kungakhale ndi gawo lofunikira pakupititsa patsogolo ntchito za ubongo, kugwira ntchito kwa thupi, ndi kukumbukira kukumbukira.

Kuchita bwino kwa Alpha-GPC

Wonjezerani mphamvu za ubongo

Kuchuluka kwa ma cell a mitsempha muubongo, mphamvu yawo imakhala yamphamvu, imatumiza mwachangu zizindikiro za minyewa, komanso mphamvu yaubongo yokonza zinthu. Alpha-GPC ikhoza kupititsa patsogolo ntchito za ubongo mwa kupititsa patsogolo mphamvu za maselo a mitsempha ndi kufalitsa mphamvu za mitsempha ya mitsempha. Pankhani yopititsa patsogolo cholinergic neurotransication, kufalikira kwa ma cell pakati pa mitsempha ya mitsempha kumadalira kufalikira kwa ma neurotransmitters, ndipo acetylcholine ndi messenger wofunikira wamankhwala ndi ma neurotransmitter omwe amatsimikizira kuganiza mozama ndikusunga mgwirizano pakati pa ubongo ndi thupi lonse. Alpha-GPC imatha kuwola kukhala 3-glycerol phosphate ndi choline mu ubongo ndipo ndiyomwe imathandizira kwambiri acetylcholine. Ikhoza kupititsa patsogolo kukumbukira ndikuwongolera kuganiza mwa kulimbikitsa kaphatikizidwe ndi kutulutsidwa kwa acetylcholine mu ubongo. Ponena za kupititsa patsogolo kukhazikika ndi kusungunuka kwa ma membrane am'maselo, Alpha-GPC imatha kulimbikitsa kaphatikizidwe ka phosphoinositide, potero kumathandizira kukhazikika komanso kusungunuka kwa ma cell membranes. Ma nyuroni okhala ndi mawonekedwe athunthu amatha kufalitsa uthenga ndikuwongolera kuganiza bwino kwa thupi. Gwiritsani ntchito.

Tetezani mitsempha

Zomwe zimayambitsa kukula kwa minofu yamanjenje, zomwe ndi neurotrophic factor, zimatha kuwongolera kusiyanasiyana kwa ma cell a stem ndikulimbikitsa kupanga kulumikizana kwatsopano kwa neural. Alpha-GPC ikhoza kulimbikitsa kutulutsidwa kwa zinthu zosiyanasiyana za neurotrophic ndikuyambitsa njira zowonetsera zokhudzana ndi kupulumuka kwa maselo, motero zimakhala ndi zotsatira za neuroprotective. Kupititsa patsogolo chidziwitso cha thupi. Panthawi imodzimodziyo, Alpha-GPC ikhoza kulimbikitsanso kutulutsa kwa hormone ya kukula ndikukhala ndi thanzi labwino la thupi powonjezera kukula kwa hormone.

Antioxidant

Kuchuluka kwa okosijeni ndi kutupa ndizomwe zimayambitsa kukalamba kwa maselo a ubongo ndi kufa. Alpha-GPC imatha kuwononga ma radicals aulere m'thupi, kuthana ndi kupsinjika kwa okosijeni, komanso kuchepetsa kutupa monga nyukiliya factor NF-κB, tumor necrosis factor TNF-α, ndi interleukin IL-6. Kutulutsidwa kwa zinthu kumalimbana ndi kutupa muubongo, motero kumachepetsa kwambiri kuchepa kwa chidziwitso ndikuletsa kuchitika ndi kukula kwa matenda a neurodegenerative. Zotsatira zoyenera zathandizidwa ndi zotsatira zachipatala.

Mu phunziro la "Zotsatira za Alpha-GPC pa Kuwonongeka kwa Memory Related Memory", maphunziro a 4 anapatsidwa placebo, ndipo maphunziro ena a 5 anapatsidwa Alpha-GPC (1200 mg / tsiku), atatha kulamulira pakamwa mosalekeza kwa miyezi 3, 16 ma electrodes adagwiritsidwa ntchito kujambula mafunde aubongo kwa mphindi 5 pomwe ophunzira anali maso ndikupumula. Zotsatira zake zidawonetsa kuti poyerekeza ndi placebo, Alpha-GPC idatha kukulitsa kwambiri gawo la mafunde othamanga kwambiri muubongo, pomwe anali ndi chizolowezi chochepetsa ma frequency ocheperako. Ndiko kuti, imatha kukulitsa nyonga yaubongo ya anthu azaka zapakati ndikuchedwetsa kukalamba kwa thupi.

Sinthani maganizo

Dopamine imapangitsa anthu kukhala osangalala, ndipo serotonin ndi gamma-aminobutyric acid zimatha kuwongolera momwe thupi likuyendera. Alpha-GPC ikhoza kulimbikitsa kutulutsidwa kwa dopamine, kuwongolera-kuwongolera mafotokozedwe a onyamula dopamine, kusintha dopamine neurotransmission muubongo, ndikuwonjezera milingo ya serotonin mu striatum ndi prefrontal cortex; ingathenso kulimbikitsa kwambiri γ- Kutulutsidwa kwa asidi aminobutyric kumachepetsa kusowa tulo, motero kumagwiritsa ntchito mphamvu zake zotsutsa-depressant, nkhawa-kuchepetsa komanso kukhazikika maganizo.

Kuonjezera apo, Alpha-GPC ikuwonekanso kuti imatha kupititsa patsogolo kuyamwa kwachitsulo chopanda heme mu chakudya, mofanana ndi zotsatira za vitamini C pa chiwerengero cha 2: 1 ndi chitsulo, kotero Alpha-GPC imatengedwa kuti ndi, kapena pa. osachepera amathandiza, kuwongola nyama mankhwala. Chodabwitsa cha mayamwidwe achitsulo cha nonheme. Kuphatikiza apo, kuphatikiza ndi Alpha-GPC kungathandizenso kuwotcha mafuta ndikuthandizira lipid metabolism. Izi ndichifukwa cha ntchito ya choline ngati michere ya lipophilic. Miyezo yathanzi yamtunduwu imatsimikizira kuti mafuta acids amapezeka ku cell mitochondria, yomwe imatha kusintha mafutawa kukhala ATP kapena mphamvu.

Zosintha zamalamulo

Alpha GPC yakhala ikugwiritsidwa ntchito kwa zaka zopitilira 10. Pakadali pano, Alpha GPC ndi chakudya chatsopano ku Japan ndipo nthawi zambiri amagwiritsidwa ntchito popanga zakudya zogwira ntchito. Kuphatikiza apo, United States, Canada, Switzerland ndi mayiko ena adavomereza motsatizana kapena kulola kuti Alpha GPC ionjezedwe ku chakudya pambuyo pa Japan. Ku United States, Alpha GPC imayendetsedwa ngati Chinthu Chodziwika Kwambiri Monga Chotetezedwa (GRAS). Ku Canada, Alpha GPC imavomerezedwa ngati mankhwala achilengedwe.

Kugwiritsa ntchito msika komanso momwe zinthu zimayendera

Poona zosakwanira deta pa chitetezo cha Alpha GPC makanda, amayi apakati, ndi amayi oyamwitsa, zochokera mfundo kupewa chiopsezo, magulu pamwamba sayenera kudya izo, ndi chizindikiro ndi malangizo ayenera kusonyeza osayenera gulu. Ku United States, Japan, Canada ndi mayiko ena, Alpha GPC yakhala ikugwiritsidwa ntchito kwambiri pazakudya. Zogulitsa zofananira zimaphimba zakudya zowonjezera, zakumwa, ma gummies ndi magulu ena, ndipo chilichonse chimakhala ndi ntchito yomveka bwino komanso yovomerezeka.

Magulu ambiri ndi ovomerezeka. Mwachitsanzo, ku United States, pali zowonjezera zakudya za 300 za Alpha GPC yokha, zomwe zimanena kuti zikuphatikizapo kupititsa patsogolo kukumbukira ndi chidziwitso, kupititsa patsogolo ntchito zamagalimoto, etc. Mlingo wa tsiku ndi tsiku ndi 300-1200 mg.
Mkhalidwe wamakono waukadaulo wopanga

Kafukufuku akuwonetsa kuti kaphatikizidwe ka mankhwala ndi imodzi mwa njira zazikulu zopangira Alpha GPC. Pogwiritsa ntchito polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide ndi madzi monga zopangira, pambuyo pa condensation ndi esterification anachita, ndi decolorized, zonyansa zimachotsedwa, zimayikirapo, zoyengedwa ndi zouma. angapezeke ndi njira zina. Komabe, kaphatikizidwe ka mankhwala azikhalidwe, mankhwala hydrolysis, mankhwala alcoholysis ndi njira zina zonse amakumana ndi mavuto monga kuipitsa chilengedwe, kukwera mtengo, ndi zovuta kukonzekera njira.

M'zaka zaposachedwa, kukonzekera kwa Alpha GPC ndi njira za bioenzymatic kwalandira chidwi chochulukirapo. Njira zamadzimadzi za enzymatic, njira zopanda madzi-gawo za enzymatic, ndi zina zambiri zawonekera. Poyerekeza ndi njira zamakina, kukonzekera kwa Alpha GPC ndi njira za bioenzymatic kumakhala ndi zochitika zochepa komanso njira zosavuta. , yothandiza kwambiri komanso yoyenera kupanga malonda akuluakulu.

Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba komanso wachiyero wa Alpha GPC Supplement powder.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Ufa wathu wa Alpha GPC Supplement umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kupititsa patsogolo thanzi lanu, Alpha GPC Supplement powder ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.

Alpha GPC imadziwika kuti ndi hygroscopic, kutanthauza kuti imatenga chinyezi kuchokera kumlengalenga wozungulira. Pachifukwa ichi, zowonjezera ziyenera kusungidwa m'mitsuko yopanda mpweya ndipo sayenera kuwululidwa ndi mpweya kwa nthawi yaitali.

Malingaliro omaliza

Alpha GPC imagwiritsidwa ntchito popereka choline ku ubongo kudutsa chotchinga chamagazi-ubongo. Ndi kalambulabwalo wa acetylcholine, neurotransmitter yomwe imalimbikitsa thanzi lachidziwitso. Zowonjezera za Alpha GPC zitha kugwiritsidwa ntchito kupindulitsa thanzi lanu lachidziwitso mwa kukonza kukumbukira, kuphunzira, ndi kukhazikika. Kafukufuku akuwonetsanso kuti Alpha GPC imathandiza kuwonjezera mphamvu za thupi ndi mphamvu za minofu.