Kodi muli paulendo wathanzi ndipo mukuyang'ana zowonjezera zowonjezera kuti mukhale ndi thanzi labwino komanso lamalingaliro? Osayang'ananso kupitilira zowonjezera 7,8-dihydroxyflavone. 7,8-Dihydroxyflavone ndi flavonoid yomwe imapezeka muzomera zina ndipo yaphunziridwa chifukwa cha ubwino wake wathanzi. Kafukufuku akuwonetsa kuti 7,8-dihydroxyflavone ili ndi neuroprotective, anti-inflammatory, and antioxidant properties, zomwe zimapangitsa kuti zikhale zowonjezera thanzi labwino. Ngati mukuyang'ana kuti mupite pamlingo wina, lingalirani zophatikizira 7,8-dihydroxyflavone muzochita zanu zatsiku ndi tsiku.
Ndiye nchiyani kwenikweni7,8-dihydroxyflavone? 7,8-DHF ndi flavonoid yomwe imapezeka muzomera ndi ndiwo zamasamba. Zinapezeka pofufuza molekyu yomwe imatsanzira ntchito ya ubongo-derived neurotrophic factor (BDNF), kamolekyu kakang'ono kamene kamayambitsa cholandilira chotchedwa tropomyosin-related kinase B (TrkB) chifukwa peptide imagwira ntchito pa Cholandilira ichi, chotchedwa ubongo- derived neurotrophic factor (BDNF), sangathe kugwiritsidwa ntchito chifukwa cha malabsorption ndi ubongo.
7,8-DHF idapezeka kuti ndi yoyeserera yamphamvu ya BDNF, ikuchita chimodzimodzi pa TrkB. Izi zikutanthauza kuti 7,8-DHF ikhoza kutulutsa zotsatira zofanana mu ubongo monga BDNF, ndipo mwachidziwitso zingakhale zothandiza kwambiri mwachirengedwe chifukwa cha kuyamwa kwake bwino komanso kutha kuwoloka chotchinga cha magazi-ubongo.
Chifukwa cha kuthekera kwake kulimbikitsa ma receptor a TrkB, ma receptors a TrkB amatenga gawo lofunikira pakukula ndi kupulumuka kwa ma neuron muubongo. Ma receptor a TrkB akayatsidwa, ma neurons amatha kukula komanso chitetezo. Kukula kumeneku nthawi zambiri kumakhudza ma dendrites a neurons, omwe amapita ku synapses kuti alankhule ndi ma neuroni omwe amatsatira, ndipo 7,8-DHF yasonyezedwa kuti imalimbikitsa kukula kwa dendrites mu synapses, kuthandiza kubwezeretsa nyama Kuyankhulana pakati pa neuroni mu chitsanzo cha chidziwitso. kuchepa.
Kafukufuku wambiri akuwonetsa kuti 7,8-DHF ikhoza kukhala ndi kuthekera kopititsa patsogolo kuphunzira ndi kukumbukira, kupewa matenda oyambitsa matenda a neurodegenerative, komanso kuthandizira kukhazikika komanso thanzi lamalingaliro. Zomwe zapezazi zadzetsa chidwi chazakudya za 7,8-dihydroxyflavone monga njira zachilengedwe zothandizira thanzi laubongo.
Anthu ambiri amatembenukira ku 7,8-dihydroxyflavone zowonjezera kuti zithandizire kuzindikira kwawo, makamaka akamakalamba kapena akukumana ndi zovuta zokhudzana ndi kukumbukira komanso kukhazikika. Lingaliro lakugwiritsa ntchito mankhwala achilengedwe kuthandizira thanzi laubongo ndikosangalatsa makamaka kwa iwo omwe amakonda njira yachilengedwe, yokhazikika paumoyo.
Chimodzi mwazinthu zazikulu zogwirira ntchito za 7,8-dihydroxyflavone ndi kuthekera kwake kuyambitsa njira yolumikizira ya tropomyosin receptor kinase B (TrkB). TrkB ndiye cholandilira cha neurotrophic factor brain-derived neurotrophic factor (BDNF) ndipo imagwira ntchito yofunika kwambiri pakukula, kupulumuka, ndi kugwira ntchito kwa ma neuron pakati ndi zotumphukira zamanjenje. Kutsegula kwa TrkB receptor ndi 7,8-dihydroxyflavone kumabweretsa phosphorylation ya intracellular domain yake, kuyambitsa mndandanda wa zochitika zowonetsera pansi, potsirizira pake kulimbikitsa kupulumuka kwa neuronal, kukula ndi kusiyana.
Kafukufuku wasonyeza kuti 7,8-dihydroxyflavone imawonetsa zotsatira za neuroprotective mumitundu ingapo ya matenda a neurodegenerative, monga matenda a Alzheimer's ndi Parkinson's. Poyambitsa njira yowonetsera ya TrkB, 7,8-dihydroxyflavone imapangitsa kuti ma neuroni apulumuke, amawateteza ku kupsinjika kwa okosijeni ndi kutupa, ndikulimbikitsa mapangidwe atsopano a synaptic, omwe angathe kuchepetsa kapena kuchepetsa kuchepa kumeneku. Kukula kwa matendawa.
Kuphatikiza pa zotsatira za neuroprotective, 7,8-dihydroxyflavone yapezeka kuti ili ndi zotsatira zodetsa nkhawa. Zotsatirazi zimaganiziridwa kuti zimakhala zoyanjanitsidwa ndi kuthekera kwake kukulitsa zotsatira za BDNF mu ubongo, potero kupititsa patsogolo pulasitiki ya neuronal ndi kupirira poyang'anizana ndi kupsinjika maganizo ndi kusokonezeka maganizo. Kuonjezera apo, kafukufuku wa preclinical wasonyeza kuti 7,8-dihydroxyflavone imatha kupititsa patsogolo kuphunzira ndi kukumbukira, kukulitsa kuthekera kwa kugwiritsidwa ntchito kwake pochiza kusokonezeka kwa chidziwitso komwe kumayenderana ndi mikhalidwe monga dementia ndi kuvulala koopsa kwa ubongo.
Umboni watsopano ukuwonetsa kuti itha kukhalanso ndi zopindulitsa pamatenda ena ndi ziwalo zina. Mwachitsanzo, 7,8-dihydroxyflavone yasonyezedwa kuti ili ndi anti-inflammatory, antioxidant katundu m'mitundu yosiyanasiyana ya ma cell ndi zinyama, zomwe zimasonyeza kuti zingatheke kuchiza matenda opweteka aakulu.
Chimodzi mwazomera zomwe zili ndi 7-8 dihydroxyflavonoids ndi Tridax procumbens, zomwe zimadziwika kuti daisy kapena Tridax daisy. Chomerachi chimachokera kumadera otentha ndipo chakhala chikugwiritsidwa ntchito mumankhwala a Ayurvedic chifukwa chamankhwala ake ambiri. Ofufuza adapeza kuti Tridax procumbens ili ndi 7 mpaka 8 dihydroxyflavonoids, zomwe zimadzetsa chidwi pakufufuza zomwe zingapindule ndi thanzi.
Chomera china chomwe chili ndi 7-8 dihydroxyflavone ndi chomera cha Godmania aesculifolia, chobadwira ku Mexico. Chomerachi chimagwiritsidwa ntchito ngati mankhwala achikhalidwe aku Mexico chifukwa cha anti-inflammatory and analgesic properties. Kafukufuku akuwonetsa kuti Godmania aesculifolia ili ndi 7-8 dihydroxyflavone, zomwe zayambitsa kufufuza kwina pakugwiritsa ntchito kwake pakuchiritsa.
Kuphatikiza pa Tridax procumbens ndi Godmania aesculifolia, zomera zina zingapo zimaganiziridwa kuti zili ndi 7-8 dihydroxyflavonoids, ngakhale kufufuza kwina kumafunika kutsimikizira kupezeka kwawo mu zomera izi. Izi zikuphatikizapo fisetin ndi acacia shrub.
1. Kupititsa patsogolo Chidziwitso: Chimodzi mwazinthu zodziwika bwino za 7,8-dihydroxyflavone zowonjezera ndi kuthekera kwake kupititsa patsogolo ntchito yachidziwitso. Kafukufuku akuwonetsa kuti 7,8-DHF imathandizira kukumbukira, kuphunzira, komanso kugwira ntchito kwaubongo wonse. Mwa kulimbikitsa kukula kwa maselo atsopano a ubongo ndi kulimbikitsa kulumikizana pakati pa ma neuroni omwe alipo, 7,8-dihydroxyflavone zowonjezera zingathandize kuthandizira thanzi lanu la ubongo ndi luso la kuzindikira.
Thandizo la 2.Mood: Kuwonjezera pa zopindulitsa zachidziwitso, zowonjezera za 7,8-dihydroxyflavone zasonyezedwa kuti zimakhala ndi zotsatira zabwino pamaganizo. Kafukufuku akuwonetsa kuti 7,8-DHF ingathandize kuwongolera ma neurotransmitters okhudzana ndi malingaliro muubongo, monga dopamine ndi serotonin, zomwe zimagwira ntchito yofunika kwambiri pakuwongolera malingaliro. Pothandizira ma neurotransmitters awa, zowonjezera za 7,8-dihydroxyflavone zingathandize kusintha malingaliro ndi thanzi labwino lamalingaliro.
3. Zotsatira za neuroprotective: 7,8-dihydroxyflavone zowonjezera zapezekanso kuti zimakhala ndi neuroprotective katundu. Izi zikutanthauza kuti atha kuteteza ubongo ndi dongosolo lamanjenje ku kuwonongeka komwe kumachitika chifukwa cha kupsinjika kwa okosijeni, kutupa ndi njira zina zovulaza. Pothandizira thanzi ndi ntchito ya ma cell a ubongo, zowonjezera za 7,8-dihydroxyflavone zingathandize kupewa matenda a neurodegenerative komanso kuchepa kwa chidziwitso chokhudzana ndi ukalamba.
4. Chithandizo cha Antioxidant: Phindu lina lalikulu la 7,8-dihydroxyflavone zowonjezera ndi antioxidant katundu. Antioxidants ndi mankhwala omwe amathandiza kuteteza thupi kuti lisawonongeke, zomwe ndi mamolekyu ovulaza omwe angapangitse matenda osiyanasiyana osatha komanso ukalamba. Pochotsa ma radicals aulere komanso kuchepetsa kupsinjika kwa okosijeni, 7,8-DHF ingathandize kuthandizira thanzi labwino komanso moyo wabwino.
5.Anti-inflammatory effect: Kutupa ndi njira yachilengedwe yomwe imathandiza thupi kulimbana ndi matenda ndikuchiritsa kuwonongeka. Komabe, kutupa kosatha kungayambitse matenda osiyanasiyana, kuphatikizapo matenda a mtima, shuga, ndi khansa. 7,8-Dihydroxyflavone zowonjezera zasonyezedwa kuti zimakhala ndi zotsatira zotsutsa-kutupa, zomwe zimathandiza kuchepetsa chiopsezo cha kutupa kosatha komanso zoopsa zomwe zimagwirizanitsidwa ndi thanzi.
Chimodzi mwazinthu zoyamba zomwe muyenera kuziganizira posankha chowonjezera cha 7,8-dihydroxyflavone ndi mtundu wa zosakaniza. Yang'anani zowonjezera zomwe zili ndi 7,8-DHF yoyera, yapamwamba kwambiri yopanda zodzaza kapena zopangira. Ndikofunikiranso kulingalira komwe kumachokera 7,8-DHF yanu - yang'anani zowonjezera zomwe zayesedwa kuti zikhale zoyera komanso zamphamvu.
Kuwonjezera pa ubwino wa zosakaniza, m'pofunikanso kuganizira mlingo ndi mawonekedwe a chowonjezera. 7,8-Dihydroxyflavone imapezeka mu capsule ndi mawonekedwe a ufa, ndipo mlingo ukhoza kusiyana pakati pa mankhwala. Chonde ganizirani zomwe mumakonda komanso zosowa zanu posankha fomu ndi mlingo womwe uli wabwino kwa inu. Zingakhalenso zothandiza kukaonana ndi dokotala kuti mudziwe mlingo womwe ukugwirizana ndi zosowa zanu.
Chinthu china chofunika kuganizira posankha chowonjezera cha 7,8-dihydroxyflavone ndi mbiri ya wopanga. Yang'anani zowonjezera zomwe zimapangidwa ndi kampani yodziwika bwino yomwe ili ndi mbiri yopanga zinthu zapamwamba, zodalirika. Yang'anani ziphaso monga Good Manufacturing Practices (GMP) ndi kuyesa kwa gulu lachitatu kuti muwonetsetse kuti zowonjezera zanu zikukwaniritsa miyezo yapamwamba komanso chitetezo.
Ndibwinonso kuwerenga ndemanga ndi maumboni ochokera kwa ogwiritsa ntchito ena kuti mumve zambiri zakuchita bwino komanso mtundu wa chowonjezera. Yang'anani ndemanga kuchokera kwa anthu omwe agwiritsa ntchito mankhwalawa kuti athandizidwe ndi chidziwitso komanso thanzi labwino laubongo kuti mumvetsetse momwe chowonjezerachi chikugwirirani ntchito.
Pomaliza, ganizirani mtengo ndi mtengo wa zowonjezera zanu. Ngakhale kuli kofunika kusankha mankhwala apamwamba, ndikofunikanso kulingalira za mtengo ndi mtengo wa zowonjezera zanu. Yerekezerani mitengo ndikuganizira mtengo uliwonse pakutumikira kuti muwonetsetse kuti mukupeza phindu la ndalama zanu.
Malingaliro a kampani Suzhou Myland Pharm & Nutrition Inc. yakhala ikuchita bizinezi yazakudya zopatsa thanzi kuyambira 1992. Ndi kampani yoyamba ku China kupanga ndi kugulitsa mbewu za mphesa.
Pokhala ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira yokongoletsedwa kwambiri ya R&D, kampaniyo yapanga zinthu zambiri zopikisana ndikukhala kampani yowonjezera ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.
Kuphatikiza apo, kampaniyo ndinso wopanga olembetsedwa ndi FDA, kuwonetsetsa kuti thanzi la anthu likhale lokhazikika komanso kukula kosatha. Zipangizo zamakampani za R&D ndi zida zopangira ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala pa milligram mpaka ton motsatira miyezo ya ISO 9001 ndi machitidwe opanga GMP.
Q: 7,8-Dihydroxyflavone ndi chiyani?
A: 7,8-Dihydroxyflavone ndi flavonoid yomwe imapezeka mwachilengedwe yomwe yaphunziridwa chifukwa cha ubwino wake wokhala ndi thanzi labwino, kuphatikizapo zotsatira zake pa ntchito yachidziwitso ndi thanzi labwino.
Q: Kodi zowonjezera 7,8-Dihydroxyflavone zimagwira ntchito bwanji?
A: 7,8-Dihydroxyflavone zowonjezera amakhulupirira kuti zimagwira ntchito pothandizira puloteni yofunika kwambiri mu ubongo yotchedwa TrkB, yomwe imakhudzidwa ndi kukula ndi kupulumuka kwa ma neuron. Thandizo ili likhoza kuthandizira kupititsa patsogolo ntchito zamaganizo ndi thanzi labwino.
Q: Ndi maubwino otani omwe mungatengere 7,8-Dihydroxyflavone supplements?
A: Ubwino wina wotengera 7,8-Dihydroxyflavone supplements ungaphatikizepo kukumbukira kukumbukira komanso kugwira ntchito kwachidziwitso, kuthandizira thanzi laubongo lonse, komanso zomwe zingapangitse kuti asangalale.
Q: Kodi zowonjezera 7,8-Dihydroxyflavone ziyenera kutengedwa bwanji?
A: Mlingo woyenera wa 7,8-Dihydroxyflavone supplements ukhoza kusiyana malingana ndi zinthu zapayekha, choncho ndi bwino kutsatira mlingo wovomerezeka pa chizindikiro cha mankhwala kapena kukaonana ndi katswiri wa zaumoyo kuti akuthandizeni.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Feb-20-2024
