Evodiamine ndi mankhwala achilengedwe omwe amapezeka mu chipatso cha chomera cha Evodiamine, chobadwira ku China ndi mayiko ena aku Asia. Zakhala zikugwiritsidwa ntchito muzamankhwala achi China kwazaka mazana ambiri chifukwa cha mapindu ake azaumoyo. Pakati pawo, evodiamine ali ndi kuthekera kwakukulu pakuwongolera kutupa ndikuthandizira kuwonda. Makhalidwe ake odana ndi kutupa amapangitsa kukhala wofunika kwambiri pochiza matenda osiyanasiyana otupa, pomwe kuthekera kwake kowonjezera thermogenesis ndikulimbikitsa lipolysis kungathandize pakuwongolera kulemera.
Kodi munayamba mwapezapo mawu oti "evodiamine" ndikudzifunsa kuti amatanthauza chiyani? Evodiamine, yochokera ku chomera Evodiamine, ndi chilengedwe chachilengedwe ku China ndi mayiko ena aku Asia. Evodiamine ali m'gulu la alkaloids lotchedwa "quinazole alkaloids," mankhwala opangidwa kuchokera ku zipatso zosapsa za zomera zomwe zimadziwika ndi mankhwala awo. Kwa zaka zambiri, mankhwala achi China akhala akugwiritsa ntchito mphamvu ya evodiamine kuti athetse matenda osiyanasiyana.
Evodiamine amadziwika chifukwa thermogenic katundu, njira imene thupi amapanga kutentha, amene angathe kumapangitsanso kagayidwe kachakudya mlingo ndi kulimbikitsa moto zopatsa mphamvu. Powonjezera thermogenesis, evodiamine ingathandize kuwotcha mafuta ndikuwongolera kulemera.
Kutupa ndi momwe thupi limayankhira kuvulala kapena matenda. Komabe, kutupa kosatha kungayambitse matenda osiyanasiyana. Mwa kuchepetsa kutupa, evodiamine ingathandize kusintha thanzi labwino komanso kuchepetsa chiopsezo cha matenda ena.
Evodiamine amadziwika kuti thermogenic katundu. Thermogenesis imatanthawuza njira yopangira kutentha m'thupi. Ndiye evodiamine imapanga bwanji kutentha kwenikweni?
Imodzi mwa njira zomwe evodiamine amachitira ndi zotsatira zake za thermogenic ndi kuyambitsa puloteni yotchedwa transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 ndi cholandirira chomwe chimapezeka makamaka mu dongosolo lamanjenje ndipo chimakhudzidwa ndi kuwongolera kutentha kwa thupi ndi metabolism. Pamene evodiamine imamangiriza ku TRPV1, imayambitsa mayankho angapo a thupi, kuphatikizapo kuwonjezereka kwa ndalama zogwiritsira ntchito mphamvu ndi thermogenesis.
Evodiamine yapezeka kuti imalimbikitsa adrenal glands kutulutsa catecholamines monga epinephrine ndi norepinephrine. Ma catecholamines amatenga gawo lofunikira pakukulitsa lipolysis, kuphwanya mafuta osungidwa kukhala mafuta acids aulere omwe angagwiritsidwe ntchito ngati gwero lamphamvu. Izi zimalimbikitsanso zotsatira za thermogenic za evodiamine.
Kuonjezera apo, evodiamine yasonyezedwa kuti imalepheretsa ntchito za michere ina yomwe imakhudzidwa ndi kupanga ndi kusunga maselo a mafuta. Mwachitsanzo, imalepheretsa kufotokoza kwa peroxisome proliferator-activated receptor gamma (PPARγ), chinthu cholembera chomwe chimalimbikitsa kudzikundikira kwa mafuta mu adipocytes. Poletsa ntchito ya PPARγ, evodiamine ingathandize kuteteza mapangidwe atsopano a mafuta ndi kuchepetsa kusungirako mafuta.
1. Kuwongolera kulemera
Chimodzi mwazinthu zodziwika bwino za evodiamine ndi kuthekera kwake ngati chithandizo chowongolera kulemera kwachilengedwe. Kafukufuku akuwonetsa kuti evodiamine imatha kuyambitsa "kutentha" zolandilira m'matupi athu, zomwe zimadziwika kuti transient receptor potential vanilloid 1 (TRPV1) receptors. Poyambitsa zolandilira izi, evodiamine ikhoza kuthandizira kukulitsa thermogenesis ndi okosijeni wamafuta, potero kukulitsa kagayidwe kachakudya ndikuchepetsa thupi. Kuphatikiza apo, imalepheretsa kukula kwa maselo atsopano amafuta, kumathandiziranso kulemera kwake.
2. Anti-kutupa katundu
Kutupa kosatha kumalumikizidwa ndi zovuta zosiyanasiyana zaumoyo, kuphatikizapo matenda amtima, shuga, ndi zina zambiri. Evodiamine amaonedwa kuti ndi mankhwala oletsa kutupa chifukwa amatha kuletsa kupanga mamolekyu oyambitsa kutupa. Kafukufuku wambiri wasonyeza kuti evodiamine ikhoza kulepheretsa ntchito ya nyukiliya-κB (NF-κB), chinthu chofunika kwambiri cholembera chomwe chimayang'anira kufotokozera kwa jini. Poletsa NF-κB, evodiamine imachepetsa kutupa mwa kuchepetsa kupanga ma cytokines opweteka monga interleukin-1β (IL-1β) ndi tumor necrosis factor-α (TNF-α).
3. Analgesic ndi analgesic katundu
Ululu, womwe nthawi zambiri umagwirizanitsidwa ndi kutupa, ndi chizindikiro china chofunikira chomwe chingakhudze kwambiri moyo. Ma analgesic properties a evodiamine akhala akuphunziridwa mozama, ndi zotsatira zolimbikitsa. Kafukufuku akuwonetsa kuti evodiamine imatha kuyambitsa njira ya transient receptor yomwe ingakhale ya vanilloid 1 (TRPV1), yomwe imakhudzidwa ndi kufalikira kwa zizindikiro zowawa. Pogwiritsa ntchito njirazi, evodiamine ikhoza kulepheretsa kumva ululu ndikupereka mpumulo kwa anthu omwe ali ndi ululu wamtundu uliwonse, kuphatikizapo ululu wa neuropathic ndi kutupa.
4. Thanzi la mtima
Kukhalabe ndi thanzi labwino la mtima ndikofunika kuti mukhale ndi thanzi labwino. Evodiamine yawonetsedwa kuti ili ndi zotsatira zabwino pamtima, monga kuchepetsa kuthamanga kwa magazi komanso kuletsa kuphatikizika kwa mapulateleti. Mwa kutsitsimutsa mitsempha ya magazi ndi kuletsa kuti magazi asapangike, evodiamine ingathandize kusintha kayendedwe ka magazi ndi kuchepetsa chiopsezo cha matenda a mtima, kuphatikizapo matenda a mtima ndi sitiroko.
5. Thanzi la M'matumbo
Evodiamine ikhoza kukhala ndi zotsatira zabwino pa thanzi la m'matumbo polimbikitsa kugaya chakudya komanso kuchepetsa kusokonezeka kwa m'mimba. Kafukufuku akuwonetsa kuti evodiamine imatha kulimbikitsa katulutsidwe ka michere ya m'mimba ndikuwongolera matumbo kuyenda bwino, potsirizira pake kuthandizira chimbudzi ndi kuchepetsa kusapeza bwino kwa m'mimba. Kuphatikiza apo, mphamvu za evodiamine zokhala ndi antimicrobial zitha kuthandizira kulimbana ndi mabakiteriya owopsa komanso kulimbikitsa thanzi lamatumbo a microbiome.
Evodiamine amatchulidwa kutengera komwe kumachokera ku zomera, Evodia rutaecarpa, yemwe amadziwika kuti Evodia fruit kapena Evodia rutaecarpa. Chomerachi chimachokera ku East Asia ndipo chakhala chikugwiritsidwa ntchito ngati mankhwala achi China kwazaka zambiri. Zipatso zosapsa za chomera cha Evodia carota ndizo gwero lalikulu la evodiamine. Izi botanical zodabwitsa lili alkaloids angapo, kuphatikizapo evodiamine, amene asonyeza phindu pa thanzi.
Zomera zina
Kuphatikiza pa Evodiamine, evodiamine imapezeka muzomera zina zingapo. Izi zikuphatikizapo Alstonia macrophylla, Evodia lepta ndi Euodia lepta, pakati pa ena. Zomerazi zimachokera kumadera osiyanasiyana a Asia, kuphatikizapo China, Japan, ndi Thailand.
Chochititsa chidwi n'chakuti, magwero a botanical amenewa sali mbali imodzi ya zomera. Ngakhale kuti zipatso zosapsa ndizo gwero lalikulu, evodiamine imathanso kuchotsedwa pamasamba, zimayambira, ndi mizu ya zomerazi. Magwero osiyanasiyanawa amapatsa ofufuza ndi asayansi mwayi wokwanira wofufuza maubwino osiyanasiyana azaumoyo ndi ntchito za evodiamine.
●Mlingo woyenera: Mlingo woyenera wa evodiamine umadalira zinthu zingapo monga zaka za wogwiritsa ntchito, thanzi, ndi zina zingapo. Kumbukirani kuti zinthu zachilengedwe sizikhala zotetezeka nthawi zonse, ndipo mlingo wake ndi wofunika. Ndikofunika kuti muwerenge zolemba zamalonda mosamala ndikufunsana ndi katswiri wa zachipatala kuti mudziwe mlingo woyenera pa zosowa zanu.
●Zoganizira pa Umoyo Wamunthu: Posankha kugwiritsa ntchito chowonjezera chilichonse, kuphatikiza evodiamine, ndikofunikira kuganizira thanzi lonse la munthu, mbiri yachipatala, ndi kulolerana kwake. Kuonjezera apo, dziwani momwe mungagwirizanitse mankhwala osokoneza bongo ndikuganiziranso za umoyo waumwini kuti muwonjezere ubwino wa evodiamine ndikuchepetsa zoopsa zilizonse.
Q: Kodi evodiamine imathandizira bwanji kutupa?
A: Evodiamine yapezeka kuti ili ndi anti-inflammatory properties. Imalepheretsa kugwira ntchito kwa mamolekyu ena otupa, monga nyukiliya factor-kappa B (NF-kB) ndi cyclooxygenase-2 (COX-2), yomwe imagwira ntchito yofunika kwambiri pakutupa. Pochepetsa kupanga mamolekyuwa, evodiamine imathandiza kuchepetsa kutupa m'thupi.
Q: Kodi evodiamine angagwiritsidwe ntchito kuchepetsa thupi?
A: Evodiamine yafufuzidwa chifukwa cha zotsatira zake pakuwonda. Amakhulupirira kuti amayambitsa njira yotchedwa thermogenesis, yomwe imawonjezera kutentha kwapakati pa thupi ndi kagayidwe kachakudya. Izi, nazonso, zitha kukulitsa ndalama zama calorie komanso zimathandizira kuchepetsa thupi. Komabe, kafukufuku wochulukirapo akufunika kuti akhazikitse mphamvu ndi chitetezo cha evodiamine pakuwonda.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Sep-26-2023
