Taurine ndi micronutrient wofunikira komanso wochuluka wa aminosulfonic acid. Amagawidwa kwambiri m'magulu osiyanasiyana ndi ziwalo za thupi. Zimapezeka makamaka mu free state mu interstitial fluid ndi intracellular fluid. Chifukwa idayamba kukhalapo mu Named pambuyo popezeka mu bile ng'ombe. Taurine imawonjezeredwa ku zakumwa zomwe zimagwira ntchito bwino kuti ziwonjezere mphamvu komanso kutopa.
Posachedwapa, kafukufuku wa taurine wasindikizidwa m'magazini atatu apamwamba a Science, Cell, ndi Nature. Maphunzirowa awulula ntchito zatsopano za taurine - anti-kukalamba, kuwongolera mphamvu ya chithandizo cha khansa, komanso kunenepa kwambiri.
Mu June 2023, ofufuza a ku National Institute of Immunology in India, Columbia University ku United States, ndi mabungwe ena anasindikiza mapepala m’magazini apamwamba a maphunziro apadziko lonse a Science. Kafukufukuyu akuwonetsa kuti kusowa kwa taurine kumayendetsa ukalamba. Kuonjezera taurine kumatha kuchedwetsa ukalamba wa nematode, mbewa, ndi anyani, ndipo kumatha kukulitsa moyo wathanzi wa mbewa zazaka zapakati ndi 12%. Tsatanetsatane: Sayansi: Mphamvu kuposa momwe mungaganizire! Taurine imathanso kusintha ukalamba ndikukulitsa moyo?
Mu Epulo 2024, Pulofesa Zhao Xiaodi, Wothandizira Pulofesa Lu Yuanyuan, Pulofesa Nie Yongzhan, ndi Pulofesa Wang Xin ochokera ku Xijing Hospital of the Fourth Military Medical University adasindikiza mapepala munyuzipepala yapamwamba yapadziko lonse lapansi ya Cell. Kafukufukuyu adapeza kuti maselo a chotupa amapikisana ndi ma CD8 + T a taurine powonetsa taurine transporter SLC6A6, yomwe imapangitsa kuti maselo a T azifa komanso kutopa, zomwe zimapangitsa kuti chotupa chitetezeke, potero kulimbikitsa kukula kwa chotupa ndi kuyambiranso, pomwe taurine imawonjezera ma cell a CD8 + T. komanso kupititsa patsogolo chithandizo cha khansa.
Pa Ogasiti 7, 2024, gulu la Jonathan Z. Long waku Stanford University (Dr. Wei Wei ndiye mlembi woyamba) adasindikiza pepala lofufuzira lotchedwa: PTER ndi N-acetyl taurine hydrolase yomwe imayang'anira kudyetsa ndi kunenepa kwambiri pamaphunziro apamwamba apadziko lonse lapansi. magazini Nature.
Kafukufukuyu adapeza N-acetyl taurine hydrolase yoyamba mu nyama zoyamwitsa, PTER, ndikutsimikizira gawo lofunikira la N-acetyl taurine pochepetsa kudya komanso kudana ndi kunenepa kwambiri. M'tsogolomu, ndizotheka kupanga ma PTER inhibitors amphamvu komanso osankhidwa pochiza kunenepa kwambiri.
Taurine imapezeka kwambiri m'matumbo a mammalian ndi zakudya zambiri ndipo imapezeka kwambiri m'magulu osangalatsa monga mtima, maso, ubongo, ndi minofu. Taurine yafotokozedwa kuti ili ndi ntchito za pleiotropic cellular ndi physiological, makamaka pankhani ya metabolic homeostasis. Kuchepetsa kwa ma genetic m'magawo a taurine kumabweretsa kukomoka kwa minofu, kuchepa kwa masewera olimbitsa thupi, komanso kusagwira bwino ntchito kwa mitochondrial m'magulu angapo. Kuphatikizika kwa taurine kumachepetsa kupsinjika kwa mitochondrial redox, kumathandizira kuchita masewera olimbitsa thupi, komanso kupondereza kulemera kwa thupi.
Biochemistry ndi enzymology ya taurine metabolism yakopa chidwi chofufuza. Mu endogenous taurine biosynthetic pathway, cysteine imapangidwa ndi cysteine dioxygenase (CDO) ndi cysteine sulfinate decarboxylase (CSAD) kuti apange hypotaurine, yomwe pambuyo pake imakhala Oxidation ndi flavin monooxygenase 1 (FMO1) imapanga taurine. Kuphatikiza apo, cysteine imatha kupanga hypotaurine kudzera njira ina ya cysteamine ndi cysteamine dioxygenase (ADO). Pansi pa taurine pawokha pali ma metabolites angapo achiwiri a taurine, kuphatikiza taurocholate, tauramidine, ndi N-acetyl taurine. Enzyme yokhayo yomwe imadziwika kuti imayambitsa njira zotsika izi ndi BAAT, yomwe imaphatikiza taurine ndi bile acyl-CoA kupanga taurocholate ndi mchere wina wa bile. Kuphatikiza pa BAAT, zizindikiritso za ma enzymes ena omwe amalumikizana ndi taurine metabolism yachiwiri sizinadziwikebe.
N-acetyltaurine (N-acetyl taurine) ndiwosangalatsa kwambiri koma osaphunzira bwino metabolite yachiwiri ya taurine. Miyezo ya N-acetyl taurine m'madzi am'madzi am'madzi amawunikidwa mwamphamvu ndi zosokoneza zingapo za thupi zomwe zimachulukitsa taurine ndi/kapena acetate flux, kuphatikiza kuchita masewera olimbitsa thupi, kumwa mowa, komanso kuwonjezera pazakudya kwa taurine. Kuphatikiza apo, N-acetyltaurine ili ndi mawonekedwe ofanana ndi mamolekyu osayina kuphatikiza neurotransmitter acetylcholine ndi unyolo wautali wa N-fatty acyltaurine womwe umayang'anira shuga wamagazi, kutanthauza kuti utha kugwiranso ntchito ngati chizindikiro cha metabolite. Komabe, biosynthesis, kuwonongeka, ndi magwiridwe antchito a N-acetyl taurine sizikudziwika.
Mu kafukufuku waposachedwa, gulu lofufuzalo lidazindikira PTER, puloteni yamasiye yomwe imagwira ntchito yosadziwika, monga mammalian N-acetyl taurine hydrolase. Mu vitro, recombinant PTER adawonetsa magawo ocheperako komanso zoletsa zazikulu. Mu N-acetyl taurine, imasinthidwa kukhala taurine ndi acetate.
Kugogoda jini ya Pter mu mbewa kumabweretsa kutayika kwathunthu kwa ntchito ya N-acetyl taurine hydrolytic mu minyewa komanso kuwonjezereka kwadongosolo muzinthu za N-acetyl taurine m'magulu osiyanasiyana.
PTER locus yamunthu imalumikizidwa ndi index ya misa ya thupi (BMI). Gulu lofufuzalo lidapezanso kuti pambuyo pokondoweza ndi kuchuluka kwa ma taurine, mbewa za Pter knockout zidawonetsa kuchepa kwa chakudya ndipo zinali zosagwirizana ndi kunenepa kwambiri chifukwa cha zakudya. ndi kusintha kwa glucose homeostasis. Kuphatikizika kwa N-acetyl taurine kuti onenepa mbewa zakuthengo kudachepetsanso kudya komanso kulemera kwa thupi motengera GFRAL.
Izi zimayika PTER pachimake enzyme node ya taurine yachiwiri metabolism ndikuwulula maudindo a PTER ndi N-acetyl taurine pakuwongolera kuwonda komanso kuwongolera mphamvu.
Ponseponse, kafukufukuyu adapeza acetyl taurine hydrolase yoyamba mu nyama zoyamwitsa, PTER, ndikutsimikizira gawo lofunikira la acetyl taurine pochepetsa kudya komanso kudana ndi kunenepa kwambiri. M'tsogolomu, zikuyembekezeredwa kuti ma PTER inhibitors amphamvu komanso osankhidwa azipangidwa kuti azitha kunenepa kwambiri.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Aug-12-2024
