Pamene tikukalamba, kusunga thanzi lathu lonse kumakhala kofunika kwambiri. Kafukufuku wofananira akuwonetsa kuti nicotinamide riboside, mtundu wa vitamini B3, imatha kulimbana ndi kukalamba kwa ma cell ndikulimbikitsa ukalamba wathanzi. Nicotinamide Riboside Kuphatikiza pakubwezeretsanso ma cell okalamba, nicotinamide riboside ikuwonetsanso lonjezano pakuwongolera thanzi labwino komanso moyo wautali. Kafukufuku wa nyama akuwonetsa kuti zowonjezera za NR zimatha kukulitsa moyo ndikusintha thanzi mumikhalidwe yosiyanasiyana yokhudzana ndi ukalamba, kuphatikiza kunenepa kwambiri, matenda amtima, ndi matenda a neurodegenerative.
Kukalamba ndi njira yachilengedwe yomwe zamoyo zonse zimakumana nazo. Monga anthu, matupi athu ndi maganizo athu zimasintha kwambiri tikamakalamba.
Kusintha koonekeratu ndi kwa khungu, ndi makwinya, mawanga a zaka, ndi zina zotero. Kuonjezera apo, minofu imakhala yofooka, mafupa amachepa mphamvu, mafupa amawuma, ndipo kuyenda kwa munthu kumakhala kochepa.
Mbali ina yofunika kwambiri ya ukalamba ndiyo kuwonjezereka kwa chiwopsezo cha matenda aakulu monga matenda a mtima, shuga, ndi mitundu ina ya khansa. Kuphatikiza apo, kuchepa kwachidziwitso ndi vuto lina lofala. Kulephera kukumbukira zinthu, kuvutika kuika maganizo pa zinthu zonse, ndiponso kuchepetsa mphamvu ya maganizo kungakhudze moyo wathu watsiku ndi tsiku.
Achikulire ambiri amasungulumwa, amavutika maganizo, kapena amada nkhaŵa, makamaka ngati akudwala kapena wachibale wawo anamwalira. Zikatere, m’pofunika kufunafuna chichirikizo chamaganizo kuchokera kwa achibale, mabwenzi, ngakhalenso akatswiri.
Ngakhale kuti sitingathe kuletsa ukalamba, pali njira zomwe tingachepetsere ukalamba ndi kukhalabe ndi maonekedwe aunyamata kwa nthawi yaitali. Zowonjezera zoletsa kukalamba ndi njira imodzi yabwino.
NAD + ndi coenzyme yofunikira yomwe imapezeka m'maselo onse amoyo. Ntchito yake yayikulu ndikupititsa patsogolo kagayidwe kazinthu zama cell pothandizira kusamutsa ma elekitironi m'njira zambiri zachilengedwe monga kupanga mphamvu. Komabe, tikamakalamba, milingo ya NAD + m'matupi athu imatsika mwachilengedwe. Kafukufuku wina akuwonetsa kuti kuchepa kwa milingo ya NAD + kungakhale chinthu chomwe chimayambitsa ukalamba.
Chimodzi mwazofunikira kwambiri pakufufuza kwa NAD + chinali kupezeka kwa molekyulu ya NAD + yotchedwa nicotinamide riboside (NR). NR ndi mtundu wa vitamini B3 womwe umasinthidwa kukhala NAD + mkati mwa maselo athu. Maphunziro angapo a nyama awonetsa zotsatira zabwino, kutanthauza kuti kuwonjezera kwa NR kumatha kukulitsa milingo ya NAD + ndikuchepetsa kuchepa kwa zaka.
Matenda ambiri okhudzana ndi ukalamba, monga matenda a neurodegenerative ndi vuto la metabolic, amalumikizidwa ndi kusokonezeka kwa mitochondrial. Mitochondria ndi mphamvu zama cell athu, omwe ali ndi udindo wopanga mphamvu. NAD+ imatenga gawo lofunikira pakusunga magwiridwe antchito abwino a mitochondrial. Poteteza thanzi la mitochondrial, NAD + ili ndi kuthekera kochepetsa chiwopsezo cha matenda obwera chifukwa cha ukalamba ndikutalikitsa moyo.
Kuphatikiza apo, NAD + imachita nawo ntchito za sirtuins, banja la mapuloteni okhudzana ndi moyo wautali. Sirtuins amawongolera njira zosiyanasiyana zachilengedwe, kuphatikiza kukonza kwa DNA, kuyankha kupsinjika kwa ma cell, komanso kutupa. NAD + ndiyofunikira kuti Sirtuin igwire ntchito, imagwira ntchito ngati coenzyme yomwe imayambitsa ntchito yake ya enzymatic. Powonjezera NAD + ndikuwonjezera ntchito ya Sirtuin, titha kuchedwetsa ukalamba ndikulimbikitsa thanzi ndi moyo wautali.
Kafukufuku wambiri wasonyeza kuti NAD + supplementation ili ndi zotsatira zabwino pazitsanzo za nyama. Mwachitsanzo, kafukufuku wina wa mbewa adawonetsa kuti kuwonjezera ndi NR kumapangitsa kuti minofu igwire bwino ntchito komanso kupirira. Kafukufuku wina wasonyeza kuti NR supplementation imatha kupititsa patsogolo kagayidwe kake ka mbewa okalamba, ndikupangitsa kuti ikhale yofanana ndi ya mbewa zazing'ono. Zotsatirazi zikusonyeza kuti NAD + supplementation ikhoza kukhala ndi zotsatira zofanana mwa anthu, ngakhale kufufuza kwina kumafunika.
Nicotinamide riboside(yomwe imadziwikanso kuti niacin) ndi mtundu wina wa niacin (wotchedwanso vitamini B3) ndipo umapezeka mwachibadwa pang'ono mu mkaka ndi zakudya zina. Ikhoza kusinthidwa kukhalaNAD + m'maselo. Monga kalambulabwalo, NR imatengeka mosavuta ndikusamutsidwa m'maselo, komwe imasinthidwa kukhala NAD + kudzera pamachitidwe angapo a enzymatic.
Maphunziro owonjezera a NR m'maphunziro a nyama ndi anthu awonetsa zotsatira zabwino. Mu mbewa, kuwonjezera kwa NR kunapezeka kuti kumawonjezera milingo ya NAD + m'magulu osiyanasiyana ndikuwongolera magwiridwe antchito a metabolic ndi mitochondrial.
NAD + imakhudzidwa ndi njira zosiyanasiyana zama cell zomwe zimatsika ndi zaka, kuphatikiza kukonza kwa DNA, kupanga mphamvu, komanso kuwongolera mawonekedwe a jini. Amaganiziridwa kuti kubwezeretsanso milingo ya NAD + ndi NR kumatha kubwezeretsa magwiridwe antchito a ma cell, potero kumapangitsa thanzi ndikutalikitsa moyo.
Kuphatikiza apo, pakufufuza kwa amuna onenepa kwambiri komanso onenepa kwambiri, kuphatikizika kwa NR kumawonjezera milingo ya NAD +, potero kumapangitsa chidwi cha insulin ndi ntchito ya mitochondrial. Zotsatirazi zikusonyeza kuti NR supplementation ikhoza kukhala ndi ntchito zomwe zingagwiritsidwe ntchito pothana ndi matenda a metabolic monga mtundu wa shuga wa 2 ndi kunenepa kwambiri.
1. Zakudya zachilengedwe za nicotinamide riboside
Chimodzi mwazinthu zomwe zingayambitse NR ndi mkaka. Kafukufuku wina wasonyeza kuti mkaka uli ndi kuchuluka kwa NR, makamaka mkaka wolimbikitsidwa ndi NR. Komabe, zomwe zili mu NR muzinthuzi ndizochepa ndipo kupeza ndalama zokwanira kudzera muzakudya zokha kungakhale kovuta.
Kuphatikiza pazakudya, zowonjezera za NR zimapezeka mu capsule kapena mawonekedwe a ufa. Zowonjezera izi nthawi zambiri zimachokera kuzinthu zachilengedwe monga yisiti kapena kuwira kwa bakiteriya. NR yochokera ku yisiti nthawi zambiri imatengedwa ngati gwero lodalirika komanso lokhazikika chifukwa imatha kupangidwa mochulukirapo popanda kudalira magwero a nyama. NR yopangidwa ndi bakiteriya ndi njira ina, yomwe nthawi zambiri imapezeka kuchokera ku mitundu ina ya mabakiteriya omwe amapanga NR.
2. Onjezani nicotinamide riboside
Gwero lodziwika komanso lodalirika la nicotinamide riboside ndi kudzera muzakudya zowonjezera. Zowonjezera za NR zimapereka njira yabwino komanso yothandiza yowonetsetsa kuti mulingo woyenera wa mankhwalawa ndi wofunikira. Posankha chowonjezera chabwino cha NR, ndikofunikira kuganizira izi:
a) Chitsimikizo Chabwino: Yang'anani zowonjezera zomwe zimapangidwa ndi makampani odziwika bwino ndikutsata miyezo yokhazikika yowongolera. Izi zidzatsimikizira kuti mumapeza mankhwala apamwamba kwambiri opanda zonyansa kapena zonyansa.
b) Bioavailability: Zowonjezera za NR zimagwiritsa ntchito machitidwe apamwamba operekera monga encapsulation kapena teknoloji ya liposome kuti apititse patsogolo bioavailability wa NR kuti athe kuyamwa bwino ndikugwiritsidwa ntchito ndi thupi. Sankhani zowonjezera izi kuti muwonjezere phindu lomwe mumapeza kuchokera ku NR.
c) Chiyero: Onetsetsani kuti chowonjezera cha NR chomwe mwasankha ndi choyera ndipo mulibe zowonjezera zosafunikira, zodzaza kapena zosungira. Kuwerenga malembo ndi kumvetsetsa zosakaniza kungakuthandizeni kupanga chisankho mwanzeru.
1. Limbikitsani kupanga mphamvu zama cell
NR imagwira ntchito yofunika kwambiri popanga molekyulu yofunikira ya nicotinamide adenine dinucleotide (NAD+). NAD + imakhudzidwa ndi njira zosiyanasiyana zama cell, kuphatikiza mphamvu metabolism. Tikamakalamba, milingo ya NAD + m'matupi athu imachepa, zomwe zimapangitsa kuti mphamvu zichepe. Polimbikitsa kaphatikizidwe ka NAD +, NR imathandizira kutsitsimutsa ma cell ndikupangitsa kupanga mphamvu moyenera. Mphamvu zama cell izi zimawonjezera mphamvu, zimathandizira magwiridwe antchito, komanso zimachepetsa kutopa.
2. Anti-kukalamba ndi kukonza DNA
Kutsika kwa milingo ya NAD + kumalumikizidwa ndi ukalamba komanso matenda okhudzana ndi ukalamba. NR imatha kukulitsa milingo ya NAD + m'thupi, ndikupangitsa kuti ikhale anti-kukalamba. NAD + imakhudzidwa ndi njira zokonzetsera DNA, kuwonetsetsa kukhulupirika kwa majini athu. Polimbikitsa kukonza kwa DNA, NR ikhoza kuthandizira kupewa kuwonongeka kwa DNA kwazaka zakubadwa ndikuthandizira kukalamba bwino. Kuphatikiza apo, ntchito ya NR poyambitsa ma sirtuin, gulu la mapuloteni omwe amadziwika kuti amawongolera thanzi la ma cell ndi moyo wautali, kumapangitsanso kuthekera kwake koletsa kukalamba.
3. Thanzi la mtima
Kukhalabe ndi thanzi labwino la mtima ndikofunika kuti mukhale ndi thanzi labwino. Nicotinamide riboside yawonetsa zotsatira zabwino paumoyo wamtima. Imathandizira ntchito ya ma cell endothelial cell, imathandizira kutuluka kwa magazi ndikuchepetsa kutupa. NR imathandiziranso ntchito ya mitochondrial m'maselo amtima, kuteteza kupsinjika kwa okosijeni komanso kukhathamiritsa kupanga mphamvu. Zotsatirazi zingathandize kuchepetsa chiopsezo cha matenda amtima monga atherosclerosis ndi kulephera kwa mtima.
4. Neuroprotection ndi ntchito yachidziwitso
NR yawonetsedwa kuti ili ndi mphamvu zoteteza ubongo, zomwe zimapangitsa kuti ikhale yothandizana nayo pakusunga thanzi laubongo. Zitha kukhala ndi zotsatira zabwino pa ntchito ya neuronal ndikuteteza ku kuchepa kwa chidziwitso chokhudzana ndi ukalamba. Powonjezera milingo ya NAD +, NR imathandizira ntchito ya mitochondrial m'maselo aubongo, imathandizira kupanga mphamvu ndikulimbikitsa kukonza ma cell. Kupititsa patsogolo ntchito ya mitochondrial kumatha kukulitsa luso lazidziwitso monga kukumbukira, kukhazikika, komanso kumveka bwino kwamaganizidwe.
5. Kulemera Kwambiri ndi Metabolic Health
Kukhala ndi thupi lolemera komanso kukhazikika kwa metabolic ndikofunikira ku thanzi lathu lonse. NR yakhala ikugwirizana ndi zotsatira zopindulitsa pa metabolism, zomwe zimapangitsa kuti zikhale zothandiza pakuwongolera kulemera. NR imayambitsa puloteni yotchedwa Sirtuin 1 (SIRT1), yomwe imayang'anira kagayidwe kachakudya monga glucose metabolism ndi kusunga mafuta. Poyambitsa SIRT1, NR ikhoza kuthandizira kuchepetsa thupi ndikuwongolera thanzi la kagayidwe kachakudya, potero kuchepetsa chiopsezo cha matenda monga kunenepa kwambiri komanso mtundu wa 2 shuga.
Q: Kodi Nicotinamide Riboside (NR) ndi chiyani?
A: Nicotinamide Riboside (NR) ndi kalambulabwalo wa Nicotinamide Adenine Dinucleotide (NAD+), coenzyme yomwe imagwira ntchito yofunika kwambiri pazachilengedwe zosiyanasiyana, kuphatikiza kupanga mphamvu ndikuwongolera magwiridwe antchito a metabolic ndi ma cell.
Q: Kodi Nicotinamide Riboside (NR) ingapindule ndi metabolism?
A: Inde, Nicotinamide Riboside (NR) yapezeka kuti imapindulitsa metabolism. Powonjezera milingo ya NAD +, NR imatha kuyambitsa ma enzymes omwe amakhudzidwa ndi metabolism, monga ma sirtuins. Kutsegulaku kumatha kupititsa patsogolo kagayidwe kachakudya, kukulitsa chidwi cha insulin, ndikuthandizira kuwongolera kulemera kwabwino.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Nov-13-2023
