Kukalamba ndi njira yomwe chamoyo chilichonse chimadutsamo. Anthu sangalepheretse kukalamba, koma amatha kuchitapo kanthu kuti achepetse ukalamba komanso matenda obwera chifukwa cha ukalamba. Gulu limodzi lalandira chidwi kwambiri - nicotinamide riboside, yomwe imadziwikanso kuti NR. Monga kalambulabwalo wa NAD +, nicotinamide riboside imaganiziridwa kuti ili ndi mphamvu yoletsa kukalamba. Mwa kukulitsa milingo ya NAD +, nicotinamide riboside imathandizira ntchito ya sirtuin, imathandizira ntchito ya mitochondrial, ndikuyambitsa njira zingapo zama cell zomwe zimakhudzidwa ndi anti-kukalamba.
Nicotinamide riboside (NR) ndi mtundu wa vitamini B3, wotchedwanso nicotinic acid kapena nicotinic acid. Ndi mankhwala opangidwa mwachilengedwe omwe amapezeka pang'onopang'ono muzakudya zina, monga mkaka, yisiti, ndi masamba ena.
NR ndiye kalambulabwalo wa nicotinamide adenine dinucleotide (NAD+), coenzyme yomwe ilipo m'maselo onse amoyo. NAD+ imatenga gawo lofunikira pazachilengedwe zosiyanasiyana, kuphatikiza kupanga mphamvu, kukonza ma DNA, komanso kuwongolera kagayidwe kake. Tikamakalamba, milingo yathu ya NAD + imakhala yochepa, zomwe zingakhudze ntchito zovutazi. Zowonjezera za NR zaperekedwa ngati njira yowonjezerera milingo ya NAD + ndikuchepetsanso kukalamba.
Ubwino wina waukulu wa NR supplementation ndi kuthekera kwake kupititsa patsogolo ntchito ya mitochondrial. Mitochondria ndi mphamvu ya selo, yomwe imapanga mphamvu zambiri za selo mu mawonekedwe a adenosine triphosphate (ATP). NR yawonetsedwa kuti imalimbikitsa kupanga kwa ATP pokulitsa milingo ya NAD +, potero kulimbikitsa kupanga mphamvu kwamphamvu komanso metabolism yama cell. Kuwonjezeka kwa kupanga mphamvu kumeneku kungapindulitse minofu ndi ziwalo zosiyanasiyana, kuphatikizapo ubongo, mtima, ndi minofu.
●Limbikitsani mphamvu zama cell
Nicotinamide riboside imagwira ntchito yofunika kwambiri popereka mphamvu ku mphamvu yama cell, mitochondria. Pagululi ndi kalambulabwalo wa nicotinamide adenine dinucleotide (NAD+), coenzyme yofunikira yomwe imakhudzidwa ndi ma cell ambiri, makamaka metabolism yamphamvu. Kafukufuku akuwonetsa kuti kuphatikizira ndi NR kumatha kukulitsa milingo ya NAD + ndikulimbikitsa kupuma kwama cell komanso kupanga mphamvu.
Miyezo ya NAD + imakonda kutsika tikamakalamba, zomwe zimatsogolera kufooka kwa mitochondrial ndikuchepetsa mphamvu zonse. Komabe, powonjezera ndi nicotinamide riboside, ndizotheka kusintha kutsika uku ndikubwezeretsanso mphamvu zaunyamata. NR yapezekanso kuti imathandizira kupirira komanso kupititsa patsogolo masewera olimbitsa thupi, ndikupangitsa kuti ikhale yosangalatsa kwa othamanga ndi anthu omwe akufuna thanzi labwino.
●Limbikitsani kukonza ma cell ndikuletsa kukalamba
Chinanso chochititsa chidwi cha nicotinamide riboside ndikuthekera kwake kulimbikitsa kukonza kwa DNA ndikuthana ndi kuwonongeka kobwera chifukwa cha ukalamba. NAD + ndi gawo lofunikira pakukonza DNA. Powonjezera NR kuti muwonjezere milingo ya NAD+, titha kukulitsa luso la cell kukonzanso DNA, potero kudziteteza ku ukalamba.
Kuphatikiza apo, NR yakhala ikukhudzidwa pakuwongolera njira zazikulu zamoyo wautali, monga ma sirtuins, omwe amagwira ntchito yofunika kwambiri kuti ma cell azikhala athanzi. Majini amoyo wautaliwa amathandizira kukhathamiritsa njira zodzitetezera ku ma cell kupsinjika ndikulimbikitsa moyo wautali. Poyambitsa ma sirtuin, nicotinamide riboside itha kuthandiza kuchedwetsa matenda obwera chifukwa cha ukalamba komanso kukulitsa thanzi lathu.
●Pewani matenda a neurodegenerative
Matenda a neurodegenerative monga Alzheimer's ndi Parkinson akuchulukirachulukira mdera lathu. Kafukufuku akuwonetsa kuti nicotinamide riboside ikhoza kukhala ndi chiyembekezo popewa matenda ofowokawa. Kafukufuku wapeza kuti utsogoleri wa NR umapangitsa kuti mitochondrial igwire ntchito, imachepetsa kupsinjika kwa okosijeni, komanso imathandizira neuroplasticity, zonse zomwe zimapangitsa kuti ubongo ukhale wathanzi.
Kuphatikiza apo, kuwonjezera kwa NR kwalumikizidwa ndi kupititsa patsogolo chidziwitso, kukumbukira kukumbukira, komanso kuyang'ana bwino komanso nthawi yayitali. Ngakhale kafukufuku wowonjezera akufunika, zoyambira izi zikuwonetsa kuti nicotinamide riboside ikhoza kukhala njira yodzitetezera kapena yothandizira anthu omwe ali pachiwopsezo cha neurodegeneration.
●Wonjezerani chidwi cha insulin
Kafukufuku wambiri awonetsa kuti NR imatha kupititsa patsogolo thanzi la metabolic. Zawonetsedwa kuti zimakulitsa chidwi cha insulin, chomwe chimapangitsa kuti shuga azikhala wathanzi komanso kupewa kukula kwa matenda amtundu wa 2. Kafukufuku wapezanso kuti kuwonjezera kwa NR kumatha kusintha lipid metabolism, potero kumachepetsa kuchuluka kwa cholesterol ndi triglyceride. Izi ndizofunika makamaka kwa anthu omwe ali ndi vuto la metabolic kapena omwe ali onenepa kwambiri kapena onenepa kwambiri.
●Ali ndi antioxidant mphamvu
Kuphatikiza apo, NR yawonetsedwa kuti imathandizira chitetezo cha ma cell kupsinjika kwa okosijeni. Kupsinjika kwa okosijeni kumachitika pakakhala kusalinganika pakati pa kupanga mitundu ya okosijeni yokhazikika (ROS) ndi kuthekera kwa thupi kuzichepetsa ndi ma antioxidants. Kuchuluka kwa kupsinjika kwa okosijeni kumatha kuwononga maselo ndikupangitsa kuti matenda osiyanasiyana achuluke, kuphatikiza khansa, matenda amtima, komanso matenda a neurodegenerative. Kafukufuku wapeza kuti kuwonjezera NR kumatha kupititsa patsogolo mphamvu ya antioxidant ya maselo ndikuchepetsa kupsinjika kwa okosijeni m'thupi.
Kafukufuku akuwonetsa kuti nicotinamide riboside imatha kuchedwetsa ukalamba powonjezera kuchuluka kwa molekyulu ya nicotinamide adenine dinucleotide (NAD+). NAD + ndi molekyu yofunika kwambiri yomwe imagwira ntchito yofunika kwambiri pa metabolism ya ma cell.
Miyezo ya NAD + mwachilengedwe imatsika tikamakalamba. Kutsika kumeneku kumatengedwa kuti ndi chifukwa chachikulu cha ukalamba. Powonjezera milingo ya NAD +, nicotinamide riboside ikhoza kuthandizira kutsika uku ndikuchepetsa kukalamba.
NAD + imakhudzidwa ndi njira zambiri zofunika zama cell, kuphatikiza kupanga mphamvu, kukonza ma DNA, ndi mawonekedwe a jini. Powonjezera milingo ya NAD +, nicotinamide riboside imatha kupititsa patsogolo njirazi ndikuwongolera magwiridwe antchito am'manja.
Kafukufuku wambiri wasonyeza zotsatira zabwino m'maselo a nyama ndi anthu. Pakafukufuku wina, ofufuza adapeza kuti nicotinamide riboside supplementation idakulitsa milingo ya NAD + mu minofu ya minofu, motero imawongolera magwiridwe antchito a mitochondrial ndikuchita masewera olimbitsa thupi mu mbewa.
Kafukufuku wina adapeza kuti nicotinamide riboside supplementation imathandizira chidwi cha insulin komanso kulolerana kwa shuga mu mbewa onenepa, prediabetes. Izi zikuwonetsa kuti nicotinamide riboside ikhoza kukhalanso ndi phindu pazaumoyo wa metabolic.
Pakafukufuku wina waung'ono wa azaka zapakati ndi achikulire, nicotinamide riboside supplementation idakulitsa milingo ya NAD + ndikuwongolera kuthamanga kwa magazi komanso kuuma kwa mitsempha, zizindikiritso ziwiri zofunika paumoyo wamtima.
Mu kafukufuku wina, ofufuza adapeza kuti nicotinamide riboside supplementation imathandizira kugwira ntchito kwa minofu ndikuletsa kutayika kwa minofu mwa okalamba. Izi zikuwonetsa kuti nicotinamide riboside ikhoza kukhala ndi maubwino omwe angakhalepo motsutsana ndi kuchepa kwa minofu yokhudzana ndi ukalamba.
Ndikoyenera kudziwa kuti kukalamba ndizovuta kwambiri zomwe zimakhudzidwa ndi zinthu zambiri, kuphatikizapo chibadwa, moyo ndi chilengedwe. Nicotinamide riboside iyenera kuwonedwa ngati chowonjezera chomwe chingathandize pang'onopang'ono kukalamba komanso kuthandizira kukalamba bwino m'malo mwa chipolopolo chamatsenga.
AngapoNAD + zotsogola zadziwika, kuphatikiza nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), ndi nicotinic acid (NA). Zotsogolazi zimasinthidwa kukhala NAD + kamodzi mkati mwa cell.
Mwa zotsogola izi, nicotinamide riboside yalandira chidwi chofala chifukwa cha kukhazikika kwake, kupezeka kwake, komanso kuthekera kokweza bwino milingo ya NAD +. NR ndi mtundu wachilengedwe wa vitamini B3 ndipo umapezeka pang'onopang'ono mu mkaka ndi zakudya zina. Zawonetsedwa kuti zimathandizira kaphatikizidwe ka NAD + ndikulimbikitsa zochitika za sirtuins, gulu la mapuloteni okhudzana ndi moyo wautali.
Ubwino umodzi wa nicotinamide riboside ndikutha kulumpha masitepe apakatikati ofunikira pakupanga kwa NAD +. Itha kusinthidwa mwachindunji kukhala NAD + popanda kufunikira kwa ma enzyme owonjezera. Mosiyana ndi izi, zotsogola zina monga nicotinamide mononucleotide zimafuna masitepe owonjezera a enzymatic okhudza nicotinamide phosphoribosyltransferase (NAMPT) kuti atembenuzidwe kukhala NAD +.
Kafukufuku wambiri adayerekeza mphamvu ya nicotinamide riboside ndi zotsogola zina za NAD +, ndipo NR nthawi zonse imabwera pamwamba. Pakufufuza koyambirira pa mbewa zokalamba, nicotinamide riboside supplementation idapezeka kuti imakulitsa milingo ya NAD +, kukonza magwiridwe antchito a mitochondrial, komanso kupititsa patsogolo magwiridwe antchito a minofu.
Kafukufuku wopangidwa mwachisawawa, wakhungu kawiri, woyendetsedwa ndi placebo mwa akuluakulu athanzi adawonetsanso zotsatira zabwino. Miyezo ya NAD + idawonjezeka kwambiri mwa omwe adatenga nicotinamide riboside poyerekeza ndi gulu la placebo. Kuphatikiza apo, iwo adanenanso zakusintha kwachidziwitso ndikuchepetsa kutopa kokhazikika.
Ngakhale ma precursors ena a NAD +, monga nicotinamide mononucleotide ndi niacin, awonetsa zotsatira zabwino pamilingo ya NAD + m'maphunziro ena, sanawonetsebe kuchuluka kwamphamvu kwa nicotinamide riboside.
Ndikofunikira kudziwa kuti ngakhale nicotinamide riboside ikuwoneka kuti ndiyothandiza kwambiri pakuwonjezeka kwa NAD +, mayankho amunthu payekha amatha kusiyana. Anthu ena atha kupeza kuti zoyambira zina, monga nicotinamide mononucleotide kapena niacin, ndizoyenera pazosowa zawo zenizeni.
Nicotinamide riboside supplements amapezeka piritsi, kapisozi, ndi mawonekedwe a ufa. Kupeza mlingo woyenera wa NR kumadalira kwambiri zinthu zosiyanasiyana, kuphatikizapo zaka, thanzi, ndi zotsatira zomwe mukufuna. Choncho, nthawi zonse ndi bwino kukaonana ndi katswiri wa zachipatala musanayambe kumwa mankhwala atsopano, chifukwa angapereke uphungu waumwini malinga ndi zosowa zanu.
Kuphatikiza apo, kutchuka kwa NR kukuchulukirachulukira komanso mitundu ingapo yomwe ikusefukira pamsika, ndikofunikira kusankha gwero lodalirika komanso lodziwika bwino. Nazi zina zofunika kuziganizira posankha chowonjezera cha NR:
1. Chiyero ndi Ubwino: Yang'anani zinthu zomwe zayesedwa ndi gulu lachitatu kuti zitsimikizire kuti zimakwaniritsa miyezo yapamwamba kwambiri. Yang'anani zowonjezera zomwe zilibe zodzaza, zowonjezera zowonongeka, ndi zowonongeka zomwe zingakhalepo.
2. Zochita Pakupanga: Sankhani zowonjezera zomwe zimapangidwa m'malo olembetsedwa ndi FDA ndikutsatira malangizo a Good Manufacturing Practice (GMP). Izi zimatsimikizira kusasinthika kwazinthu, chitetezo ndi mphamvu.
4. Mbiri ndi Ndemanga za Makasitomala: Yang'anani ndemanga zamakasitomala ndi mavoti kuti mudziwe momwe zowonjezera zimagwirira ntchito komanso kukhutitsidwa kwamakasitomala.
Q: Kodi Nicotinamide Riboside (NR) imagwira ntchito bwanji?
A: Nicotinamide Riboside (NR) imagwira ntchito pokulitsa milingo ya NAD + m'thupi. NAD + imakhudzidwa ndi kupanga mphamvu zama cell, kukonza DNA, ndikusunga thanzi ndi magwiridwe antchito a mitochondria.
Q: Kodi Nicotinamide Riboside (NR) ingakhudze zotani?
A: Nicotinamide Riboside (NR) yawonetsa zolimbikitsa zoletsa kukalamba kudzera mu gawo lake pakukulitsa milingo ya NAD +. Kuchulukitsa kwa NAD + kumatha kupititsa patsogolo ntchito ya mitochondrial, kupititsa patsogolo kupanga mphamvu zama cell, komanso kulimbikitsa kukonza kwa DNA, zonse zomwe zingathandize kuthana ndi kuchepa kwa ukalamba komanso kukonza thanzi labwino.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Nov-10-2023
