M'madera a biochemistry ndi mankhwala, Spermine (polyamine), monga biomolecule yofunikira, yalandira chidwi chofala chifukwa cha gawo lalikulu la kukula kwa maselo, kufalikira ndi njira zosiyanasiyana zamoyo. Pomwe kafukufuku wokhudza thanzi, ukalamba ndi ntchito zama cell zikupitilirabe, kufunikira kwa Spermine kukukulirakulira. Komabe, pali ambiri opanga ma Spermine pamsika, ndipo momwe angapezere wopanga wodalirika wa Spermine wakhala ntchito yofunikira kwa ofufuza ndi mabizinesi. Mukafuna wopanga ma spermine odalirika, ndikofunikira kusankha wogulitsa wodalirika.Suzhou Mylandchakhala chisankho choyamba cha ofufuza ambiri asayansi ndi mabizinesi okhala ndi zinthu zoyera kwambiri, thandizo laukadaulo la akatswiri komanso mitengo yampikisano. Kaya mukuchita kafukufuku wofunikira kapena kakulidwe ka ntchito, Suzhou Mailun Biotechnology ikhoza kukupatsirani Spermine yapamwamba kwambiri kuti ikuthandizeni paulendo wanu wa kafukufuku wasayansi ndi luso lazopangapanga. Mukasankha Suzhou Myland, simudzapeza zinthu zokha, komanso bwenzi lodalirika.
Spermine amatchulidwa ngati polyamine, gulu la mankhwala omwe amadziwika ndi kukhalapo kwa magulu angapo a amine. Polyamines, kuphatikizapo putrescine, spermidine, ndi spermine, ndizofunikira kuti maselo akule ndi kugwira ntchito. Amagwira nawo ntchito zosiyanasiyana zamoyo monga kuchuluka kwa maselo, kusiyanitsa, ndi apoptosis. Mwachindunji, umuna umachokera ku kutembenuka kwa enzymatic kwa spermidine, polyamine ina.
Spermine ndi polyamine yomwe ili ndi magulu awiri a amino ndi magulu awiri a imino, omwe ali ndi ntchito yofunikira yolimbikitsa kukula kwa maselo. Spermine, monga organic pawiri yomwe imagwira ntchito yofunika kwambiri pazamoyo, matanthauzo ake ndi mawonekedwe ake ndi mutu wofunikira pankhani ya biology ndi chemistry.
Izi sizimangokhala zapadera, zomwe zimakhala ndi magulu angapo amino ndi amino, komanso zimagwira ntchito yofunika kwambiri pazamoyo. Spermine ndi kristalo wopanda mtundu wolimba.
Amasungunuka mosavuta m'madzi pa kutentha kozungulira, ndipo akaphatikizidwa, amapanga yankho ndi makhalidwe amchere. Mwa mankhwala, umuna umatulutsa poizoni wa nitrogen oxide ukawotchedwa, zomwe zimafunika chisamaliro chapadera pogwira ndi kusunga umuna.
Mu vivo, njira yophatikizira ya umuna imaphatikizapo kusinthika kwa enzymatic pakati pa putrescine (pawiri yosavuta ya diamine) ndi S-adenosylmethionine. Njirayi imaphatikizapo machitidwe ovuta a biochemical, kusonyeza kusiyana ndi kufunikira kwa ma enzyme mu zamoyo.
Spermine ndi spermidine zimapezeka palimodzi mu mabakiteriya ndi maselo ambiri a nyama, ndipo zonsezi ndi zinthu zofunika kwambiri pakukula kwa maselo. Imodzi mwa ntchito zazikulu zamoyo za umuna ndikulimbikitsa kukula kwa maselo. Spermine imagwira ntchito yofunika kwambiri pakugawanika kwa maselo ndi kukula, makamaka pakukhazikika kwa DNA komanso kaphatikizidwe ka mapuloteni.
Itha kuwonetsanso zinthu za polycationic pansi pa acidic, zomwe zimalola umuna kumangirira ku DNA, RNA ndi mamolekyu ena, potero zimakhudza magwiridwe antchito ndi kapangidwe ka maselo.
Malinga ndi kamangidwe kake, umuna ukhoza kuonedwa ngati chinthu china chochokera ku amino acid. Mapangidwe ake ovuta a tetraamine amamupatsa mwayi wapadera wachilengedwe komanso ntchito zowongolera thupi.
Mu biochemical classification, spermine, putrescine, spermidine, etc. palimodzi amapanga gulu la polyamines ambiri alipo mu zamoyo. Mamolekyuwa amagwira ntchito powongolera kafotokozedwe ka majini, kuwongolera kayendedwe ka maselo, komanso kutenga nawo mbali m'njira zosiyanasiyana zowonetsera ma cell. udindo wofunikira.
Choncho, umuna si molekyu wamba wa organic, komanso chigawo chapakati pa kayendetsedwe kabwino ka moyo. Kafukufuku wake akukhudza magawo angapo amitundu yosiyanasiyana monga biology ya mamolekyulu, genetics, ndi pharmacology.
Kodi autophagy ndi chiyani?
Autophagy ndi njira yofunikira mkati mwa ma cell omwe amasunga magwiridwe antchito a cell powononga ndikubwezeretsanso mapuloteni owonongeka ndi organelles. Autophagy imatha kuchotsa zinthu zovulaza m'maselo, kuthandizira ma cell kupulumuka zovuta, kulimbikitsa thanzi la ma cell ndikutalikitsa moyo.
Udindo wa autophagy mu anti-kukalamba
Chotsani zinyalala zama cell: Tikamakalamba, mapuloteni ambiri owonongeka ndi organelles amaunjikana m'maselo. Zinthu zovulazazi zimatha kusokoneza magwiridwe antchito a cell ndikuyambitsa ukalamba ndi matenda. Autophagy imatha kuwononga zinyalala izi, kusunga thanzi la maselo, ndikuchedwetsa ukalamba.
Pitirizani kukhala ndi thanzi la mitochondrial: Mitochondria ndi mafakitale amphamvu a maselo, ndipo kuchepa kwa ntchito yawo ndi chimodzi mwa zifukwa zofunika kwambiri za ukalamba. Autophagy imachedwetsa ukalamba wa ma cell pochotsa mitochondria yomwe yawonongeka, kusunga mitochondrial, ndikuchepetsa kupanga mitundu yoyipa ya okosijeni (ROS).
Limbikitsani kupulumuka kwa ma cell: Autophagy imatha kupereka chithandizo champhamvu kuti ma cell apulumuke pamene zakudya zikusowa. Kuphatikiza apo, autophagy imalimbikitsanso kudzikonzanso kwa maselo oyambira ndi kusinthika kwa minofu, kusunga unyamata wa thupi.
Spermine: choyambitsa chilengedwe cha autophagy
Spermine ndi polyamine pawiri yomwe imapezeka mwachilengedwe mu zamoyo zonse zomwe zimalimbikitsa kwambiri autophagy. Kafukufuku wapeza kuti spermine exogenous supplementation imatha kukulitsa moyo wazinthu zosiyanasiyana, kuphatikiza yisiti, nematodes, ntchentche za zipatso, ndi mbewa.
Limbikitsani autophagy: Spermine induces autophagy poletsa acetyltransferase (monga EP300), motero amachotsa zinthu zovulaza m'maselo ndi kupewa matenda okhudzana ndi ukalamba.
Anti-yotupa ndi antioxidant: Spermine ili ndi anti-yotupa ndi antioxidant katundu, imathandizira kagayidwe kake ka mitochondria, imalimbikitsa homeostasis ya protein, ndikuteteza thanzi la ma cell.
Limbikitsani chitetezo chamthupi: Spermine imatha kulimbikitsa kupanga ma cell a kukumbukira T, kuteteza kukalamba kwa chitetezo chamthupi, komanso kukulitsa kukana matenda a thupi.
zofukufuku
Kutalika kwa moyo: Kuphatikizika kwa umuna wa exogenous kumatha kukulitsa moyo wa zamoyo zosiyanasiyana. Mwachitsanzo, kudyetsa mbewa umuna unatalikitsa moyo wawo ndi anasonyeza mtima ndi neuroprotective zotsatira.
Anticancer ndi chitetezo cha mtima: Spermine imathandizira kuwunika kwa chitetezo chamthupi komanso chitetezo chamtima poyambitsa autophagy. Mu mbewa, zotsatirazi zimatayika pamene autophagy imaletsedwa.
Amachepetsa kutupa ndikuwonjezera chitetezo chamthupi: Kafukufuku akuwonetsa kuti umuna ukhoza kuchepetsa mayankho otupa ndikuwongolera magwiridwe antchito a chitetezo chamthupi polimbikitsa kupanga ma cell a kukumbukira T.
Monga njira yofunika yotetezera ma cell, autophagy imagwira ntchito yofunika kwambiri pakuletsa kukalamba. Spermine, monga inducer yachilengedwe ya autophagy, imakhala ndi zotsatirapo zazikulu pakuchedwetsa ukalamba komanso kupewa matenda okhudzana ndi kulimbikitsa autophagy, anti-inflammatory and antioxidant mechanism. Kuchulukitsa kudya kwa umuna kudzera muzakudya kapena zowonjezera zitha kukhala njira yabwino yolimbikitsira ukalamba wathanzi.
1. Thanzi la Maselo ndi Kukula
Ubwino wina waukulu wa umuna ndi ntchito yake polimbikitsa thanzi la ma cell ndi kukula. Spermine ndiyofunikira kuti ma cell achuluke komanso amasiyanitse ndipo ndizofunikira pakukonzanso minofu ndi kusinthika. Imakhazikika kapangidwe ka DNA ndi RNA ndikuwonetsetsa kuti ma cell amagwira ntchito bwino. Izi ndizofunikira makamaka pankhani ya kuchira kwa chilonda ndi kuchira kovulala, komwe kugawanika kwa maselo mwachangu ndikofunikira.
Kuonjezera apo, umuna wasonyezedwa kuti umateteza maselo ku nkhawa ya okosijeni, yomwe ingayambitse kuwonongeka kwa maselo ndi kukalamba. Poletsa ma radicals aulere, umuna umathandizira kusunga umphumphu wa maselo ndikugwira ntchito, zomwe zimathandizira ku thanzi komanso moyo wautali.
2. Anti-kukalamba katundu
Tikamakalamba, matupi athu amasinthasintha, kuphatikizapo kuchepa kwa ma polyamines monga spermine. Kafukufuku akuwonetsa kuti umuna ukhoza kukhala ndi zinthu zoletsa kukalamba, zomwe zimapangitsa kuti zikhale zowonjezera pazosamalira khungu ndi zinthu zaukhondo. Kukhoza kwake kulimbikitsa kukula kwa maselo ndi kukonza kungathandize kuthana ndi zizindikiro zowoneka za ukalamba, monga makwinya ndi khungu lofooka.
Kuphatikiza apo, antioxidant ya spermine imagwira ntchito yofunika kwambiri pakuchepetsa kupsinjika kwa okosijeni, zomwe zimathandizira kukalamba. Mwa kuphatikiza umuna muzochita zanu zosamalira khungu, simumangowonjezera maonekedwe a khungu lanu, komanso mumathandizira thanzi lake pama cell.
3. Thandizo la chitetezo cha mthupi
Chitetezo champhamvu cha mthupi ndi chofunikira pa thanzi lonse, ndipo umuna ukhoza kuthandizira kuti chitetezo cha mthupi chitetezeke. Kafukufuku akuwonetsa kuti umuna ukhoza kusintha momwe chitetezo cha mthupi chimayankhira ndikuthandiza thupi kuteteza ku matenda ndi matenda. Zasonyezedwa kuti zimalimbikitsa kupanga maselo oteteza thupi, monga ma lymphocyte, omwe ndi ofunika kwambiri polimbana ndi tizilombo toyambitsa matenda.
Kuphatikiza apo, anti-inflammatory properties za spermine zingathandize kuchepetsa kutupa kosatha, komwe kumayenderana ndi matenda osiyanasiyana, kuphatikizapo matenda a autoimmune ndi matenda aakulu. Pothandizira chitetezo cha mthupi, umuna ukhoza kulimbikitsa mphamvu ya thupi yolimbana ndi matenda.
4. Mphamvu ya neuroprotective
Ubongo ndi chimodzi mwa ziwalo zovuta kwambiri m'thupi la munthu, ndipo ndikofunikira kuti ukhale wathanzi. Spermine yapeza chidwi chifukwa cha zotsatira zake za neuroprotective, zomwe zingathandize kupewa matenda a neurodegenerative. Kafukufuku akuwonetsa kuti spermine imatha kuteteza ma neuron ku kuwonongeka komwe kumachitika chifukwa cha kupsinjika kwa okosijeni ndi kutupa, zomwe zimalumikizidwa ndi matenda monga Alzheimer's ndi Parkinson's disease.
Kuonjezera apo, umuna umagwira ntchito mu ubongo, zomwe zimakhudza kutulutsidwa kwa ma neurotransmitters, omwe ndi ofunikira kuti azilankhulana pakati pa maselo a mitsempha. Pothandizira thanzi la neuronal ndi ntchito, umuna ukhoza kuthandizira kupititsa patsogolo chidziwitso ndikuchepetsa chiopsezo cha matenda a neurodegenerative.
Ponena za mafakitale ogwiritsira ntchito pansi, umuna uli ndi ntchito zambiri. Choyamba, spermine ndi yofunika kwambiri pakati pa mankhwala ndipo amagwiritsidwa ntchito kwambiri mu mankhwala oletsa khansa ndi mankhwala a mtima. Kuchita kwake kwabwino, chitetezo ndi kukhazikika kumakondedwa ndi makampani opanga mankhwala.
Kachiwiri, spermine ndi wamba anionic surfactant ndi zabwino emulsification, malowedwe ndi decontamination mphamvu. Choncho, chimagwiritsidwa ntchito makampani mankhwala, mankhwala, ulusi, mchere processing, electroplating ndi madera ena, makamaka zodzoladzola, otsukira mano, shampu ndi mankhwala ena. imagwira ntchito yofunika kwambiri popanga zinthu.
Kuphatikiza apo, umuna ungagwiritsidwenso ntchito ngati wapakatikati wa mankhwala ophera tizilombo a organophosphorus, kukulitsa ntchito yake mumakampani ophera tizilombo. Potsirizira pake, umuna, monga chinthu chofunikira chomwe chimalimbikitsa kukula kwa maselo, amagwiritsidwanso ntchito m'munda waulimi. Ikhoza kupititsa patsogolo mayamwidwe ndi kugwiritsa ntchito zakudya zoyenera ndi mbewu, ndikuwonjezera zokolola ndi ubwino.
Pamene biotechnology, thanzi lachipatala, ndi misika yosamalira anthu ikupitilira kukula, chiyembekezo chogwiritsa ntchito umuna monga chopangira chachikulu chimakhala ndi chiyembekezo. Makamaka pazamankhwala, kuthekera kwake pakufufuza ndi chitukuko chamankhwala odana ndi chotupa, chithandizo cha cell ndi chithandizo cha matenda a chibadwa chikukopa kuchuluka kwa kafukufuku wasayansi ndi ntchito zaukadaulo, zomwe zikuwonetsa kuti zitha kukhala chiwongolero chofunikira pakukula kwamakampani. tsogolo.
Nthawi yomweyo, umuna umagwiritsidwa ntchito kwambiri ngati moisturizer yothandiza kwambiri komanso kukonza khungu pamakampani opanga zodzoladzola, kuwonetsa kukonda kwa ogula pazinthu zachilengedwe komanso zogwira mtima kwambiri zosamalira khungu, ndikuyendetsa kufunikira kwa umuna pamsika wapamwamba kwambiri wazinthu zokongola.
Kuonjezera apo, m'munda waulimi, ngakhale kuti kufunikira kwachepa m'misika yachikhalidwe monga acephate, kufufuza kwa spermine monga cholimbikitsa kukula kwa zomera kukuyembekezeka kutsegula njira yatsopano yogwiritsira ntchito ulimi wobiriwira ndikuyankha zofuna zapadziko lonse lapansi. ulimi wokhazikika. mayankho akufunika mwachangu.
Malinga ndi luso laukadaulo, kupita patsogolo kosalekeza kwaukadaulo wa kaphatikizidwe ka umuna ndi kukhathamiritsa kwamitengo kumathandizira kupanga bwino komanso kupikisana kwazinthu, ndikubweretsa chitukuko chokulirapo kumakampani. Kuphatikizidwa ndi chithandizo chamagulu ndi chitsogozo chokhazikika cha sayansi ya zamankhwala ndi ulimi wobiriwira, malo abwino akunja amangidwa kuti apititse patsogolo ntchito zaumuna.
M'madera a biochemistry ndi mankhwala, Spermine (polyamine), monga biomolecule yofunikira, yalandira chidwi chofala chifukwa cha gawo lalikulu la kukula kwa maselo, kufalikira ndi njira zosiyanasiyana zamoyo. Pomwe kafukufuku wokhudza thanzi, ukalamba ndi ntchito zama cell zikupitilirabe, kufunikira kwa Spermine kukukulirakulira. Komabe, pali ambiri opanga ma Spermine pamsika, ndipo momwe angapezere wopanga wodalirika wa Spermine wakhala ntchito yofunikira kwa ofufuza ndi mabizinesi.
Pakati pa opanga ma Spermine ambiri, Suzhou Myland imadziwika chifukwa chazinthu zake zabwino kwambiri komanso ntchito zamaluso. Spermine yoperekedwa ndi Suzhou Myland ili ndiNambala ya CAS ya 71-44-3 ndi chiyero choposa 98%.Izi zoyera kwambiri sizimangokwaniritsa miyezo yapadziko lonse lapansi, komanso zimayesedwa mwamphamvu kuti zitsimikizire kuti gulu lililonse lazinthu limatha kukwaniritsa zofunikira za kafukufuku wasayansi ndi ntchito zamafakitale.
1. Chitsimikizo cha Ubwino
Suzhou Myland amadziwa bwino lomwe kuti mtundu wazinthu ndiye mwala wapangodya wa kupulumuka ndi chitukuko chabizinesi. Kampaniyo ili ndi zida zopangira zapamwamba komanso njira yoyendetsera bwino kwambiri kuti zitsimikizire kuti zinthu zonse za Spermine zimayesedwa mozama ndikutsimikizira. Kaya ndikugula zinthu zopangira kapena gawo lililonse lazopanga, Suzhou Myland imayesetsa kuchita bwino kuti iwonetsetse kuti zinthu zake ndi zachiyero komanso zapamwamba kwambiri.
2. Professional luso thandizo
Kuphatikiza pakupereka Spermine yapamwamba kwambiri, Suzhou Myland imaperekanso makasitomala chithandizo chaukadaulo. Kaya ndi kagwiritsidwe ntchito kazinthu, malo osungira, kapena kapangidwe kofananirako koyesera, gulu laukadaulo lakampani litha kupatsa makasitomala malangizo ndi malingaliro atsatanetsatane. Utumiki woganizirawa sikuti umangowonjezera kukhutira kwamakasitomala, komanso umapangitsa kuti makasitomala azikhulupirira kwambiri malonda.
3. Mtengo wopikisana
Pamaziko owonetsetsa kuti zinthu zili bwino, Suzhou Myland yadziperekanso kupatsa makasitomala mitengo yampikisano. Mwa kukhathamiritsa njira zopangira ndi kasamalidwe ka chain chain, kampaniyo imatha kuchepetsa mtengo, potero imabweretsanso mitengo yotsika mtengo kwa makasitomala. Izi zimathandiza mabungwe ofufuza asayansi ndi mabizinesi kuti apeze Spermine yapamwamba pamitengo yabwino komanso amalimbikitsa kupita patsogolo kwa kafukufuku wokhudzana.
Momwe mungagule
Ngati mukuyang'ana wopanga ma Spermine odalirika, Suzhou Myland mosakayikira ndi chisankho chodalirika. Mutha kudziwa zambiri kudzera patsamba lovomerezeka lakampani kapena kulumikizana ndi gulu logulitsa mwachindunji. Kaya ndi zosowa zazing'ono zoyesera kapena ntchito zazikulu zamakampani, Suzhou Myland ikhoza kupereka mayankho osinthika malinga ndi zosowa zamakasitomala.
Q:Kodi umuna ndi chiyani, ndipo umapezeka kuti?
A: Spermine ndi polyamine yopezeka mwachilengedwe yomwe imapezeka m'maselo onse amoyo. Amapezeka makamaka m'magulu ambiri monga ubongo, chiwindi, ndi prostate. Spermine imakhudzidwa ndi njira zosiyanasiyana zamoyo, kuphatikizapo kukula kwa ma cell, kusiyanitsa, ndi kukhazikika kwa DNA.
Q:Kodi umuna ungaphatikizidwe bwanji muzakudya zanga?
A:Umuna umapezeka muzakudya zosiyanasiyana, makamaka mu:
● Zakudya zofufumitsa (monga tchizi ndi msuzi wa soya)
● Nyama zina (monga nkhuku ndi ng'ombe)
●Nsomba
● Njere zonse
●Nkhumba
Kuonjezera apo, zowonjezera za spermine zilipo kwa iwo omwe akufuna kuwonjezera kudya.
Q:Kodi umuna ungapindulitse thanzi la khungu?
A: Inde, umuna umadziwika chifukwa cha thanzi lake pakhungu. Zitha kuthandizira kusintha khungu, kuchepetsa maonekedwe a mizere yabwino ndi makwinya, komanso kulimbikitsa khungu lonse. Ma antioxidant ake amathandizanso kuteteza khungu kuti lisawonongeke ndi chilengedwe, ndikupangitsa kuti likhale lodziwika kwambiri pazinthu zosamalira khungu.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Oct-18-2024
