Kodi Glycerylphosphocholine Ingalimbikitse Bwanji Ubongo Wanu?

Glycerylphosphocholine (GPC, yomwe imadziwikanso kuti L-alpha-glycerylphosphorylcholine kapena alphacholine)ndi gwero lachilengedwe la choline lomwe limapezeka muzakudya zosiyanasiyana (kuphatikizapo mkaka wa m'mawere) ndipo m'maselo onse aumunthu Muli ndi choline chochepa. GPC ndi molekyu yosungunuka m'madzi yomwe yasonyezedwa kuti ndi gwero lamphamvu la choline yachipatala kuposa choline kapena phosphatidylcholine (PC) kuchokera ku zakudya kapena zowonjezera.

GPC yoyendetsedwa pakamwa imalowetsedwa bwino ndipo imang'ambika mkati mwa ma enterocyte kukhala glycerol-1-phosphate ndi choline. Atatha kudya GPC, milingo ya choline mu plasma idakwera mwachangu ndipo idakhalabe yayitali kwa maola 10. Kuchulukirachulukira kwa plasma kwa choline kumapangitsa kuyenda kwake koyenera kudutsa chotchinga chamagazi-muubongo. Izi zimawonjezera masitolo a choline mkati mwa neuroni, komwe amagwiritsidwa ntchito popanga PC ndi acetylcholine.

Mwachindunji, α-GPC ndi choline pawiri womangidwa ku glycerol molekyulu kudzera phosphate gulu, ndipo ndi choline okhala phospholipid. Zomwe zili mu choline ndizokwera kwambiri, zomwe zimawerengera pafupifupi 40%, zomwe zikutanthauza kuti 1000 mg ya α-GPC imatha kupanga pafupifupi 400 mg ya choline yaulere.

Choline ndi michere yofunikira yomwe imapezeka muzakudya zamkaka ndi mazira omwe amathandiza ma cell kuti asunge nembanemba. Choline palokha ndiyofunikanso kupanga acetylcholine. Ngakhale alpha-GPC ndi choline zina monga phosphatidylcholine ndi lecithin zingalimbikitse kupanga acetylcholine, alpha-GPC imakhala yopambana chifukwa lipids yomwe imapereka kwenikweni imapangitsa kuti maselo azitha kuyamwa mosavuta, Kuposa 90% ya phosphatidylcholine imatengedwa ndi mitsempha ya lymphatic. , pamene α-GPC imakhudzidwa kwambiri ndi mitsempha ya pakhomo, kotero kuti kuyamwa kumakhala kwakukulu, motero kumalimbikitsa kupanga acetylcholine bwino. Acetylcholine ndi neurotransmitter yomwe imagwira ntchito yofunika kwambiri pakuwongolera magwiridwe antchito aubongo ndi kuwongolera minofu. Ngakhale kuti tikhoza kudya choline kudzera mu chakudya, kuchuluka kwa acetylcholine kumachepa ndi zaka.

Ubwino wa GPC Yogwirizana ndi Kafukufuku

Ubongo umagwira ntchito

• Imawongolera kukumbukira, kukhazikika komanso nthawi yochita mwa okalamba ndi achichepere
• Imalimbikitsa kupanga ndi kutulutsidwa kwa acetylcholine (ACh) kuchokera ku ma neuroni komanso mwina ma cell ena.
• Akhoza kubwezera kuchepa kwa ACh chifukwa cha ukalamba, kuchepa kwa estrogen (kusiya kusamba, mwinanso kugwiritsa ntchito njira zakulera zapakamwa)
• Kupititsa patsogolo machitidwe a EEG
• Amachulukitsa kupanga dopamine, serotonin ndi GABA18.
• Kupititsa patsogolo ntchito ya mitochondrial panthawi ya ischemia / oxidative stress
• Imalimbana ndi kuchepa kwa zaka zokhudzana ndi msinkhu wa maselo a ubongo ndi ACh receptor manambala, ntchito ya minofu ndi kukula kwa hormone
• Limbikitsani kutulutsa kwa timadzi ta kukula kwa achinyamata ndi akuluakulu
• Amachulukitsa okosijeni wamafuta, mphamvu ya minofu ndi nthawi yochitapo kanthu, mwina kuwongolera bwino, makamaka kwa okalamba.

Kukonza Ubongo ndi Chithandizo cha Alzheimer's/Dementia

• Kupititsa patsogolo kuchira kwa ubongo pambuyo pa sitiroko, kuvulala koopsa kwa ubongo, ndi opaleshoni (asanayambe kapena atatha opaleshoni).
• Kukonza minofu yotchinga magazi ndi ubongo yomwe yawonongeka chifukwa cha matenda oopsa
• Kupititsa patsogolo kuzindikira ndi chikhalidwe cha anthu mu matenda a Alzheimer's, vascular/senile dementia, ndi Parkinson's disease.
• Chepetsani kuchepa kwa ubongo mofanana ndi matenda a Alzheimer's
• Zingakhale zopindulitsa pa matenda omwe amafunikira kukonzanso kwa myelin ndi Duchenne muscular dystrophy Choline ntchito mu metabolism yaumunthu ndi GPC

Zapadera monga gwero lamphamvu la choline, chomangira cha acetylcholine ndi chinthu chomwe chimapangitsa kaphatikizidwe kake ndi katulutsidwe.

• Acetylcholine ndi neurotransmitter mu ubongo ndi transducer chizindikiro kwinakwake m'thupi, yofunika kwambiri kwa kugunda kwa minofu, kamvekedwe ka khungu, m'mimba motility, ndi ntchito zina minofu. Mosiyana ndi choline / PC yoperekedwa kudzera mu zakudya kapena zowonjezera, GPC supplementation inasonyezedwa kuti ili ndi zotsatira zolimbikitsa kwambiri pa kaphatikizidwe ka ACh ndi kumasulidwa kwake ku maselo a cholinergic.

Kuphatikizika kwa GPC kumabweretsa kuwonjezereka kwa cholinergic signature mu ma neuron ndi ma cell ena omwe angapangitse acetylcholine. Izi ndizopindulitsa makamaka pamene chiwerengero ndi ntchito yabwino ya cholinergic neurons yafupika chifukwa cha ukalamba wamba kapena njira zosiyanasiyana zowonongeka. Kuphatikizika ndi GPC kumatha kubwezera pang'ono kuwonongeka kumeneku chifukwa kumayambitsa kukwera kofulumira kwa choline ya plasma, yomwe imakhala ndi gawo lamphamvu la gawo lapansi pama enzymes ndi onyamula m'njira izi.

Zomangamanga za phosphatidylcholine (PC)

• PC ndi ya phospholipids ndipo ndi gawo lofunika kwambiri la ma cell ndi mitochondrial nembanemba. Kuthekera kwa GPC supplementation kuti athandize kuchira kwa stroke, komanso kuthana ndi kuchepa kwa zaka zokhudzana ndi zaka za chiwerengero cha ACh zolandilira m'maselo a mitsempha kapena ubongo, ndi umboni wowonjezereka wa chithandizo chake pakukonza nembanemba ya neuronal kudzera mu kaphatikizidwe ka PC.

Kupanga kwa sphingomyelin

• Sphingomyelin ndi gawo la myelin sheath yomwe imaphimba ndi kutsekereza ma neurons ndi mitsempha. Choncho, GPC supplementation ingakhale yothandiza muzochitika zilizonse ndi kuchuluka kwa kufunikira kwa kukonza kwa myelin, monga matenda a ubongo, multiple sclerosis, ndi zina zomwe zimakhudza kutayika kwa mitsempha ndi autoimmunity ya minofu yamanjenje. Kunyamula mafuta mkati ndi kunja kwa ma cell

• PC ndi yofunika kuti kaphatikizidwe ndi katulutsidwe wa VLDL particles. Ma triglycerides amachoka m'chiwindi mkati mwa tinthu tating'ono ta VLDL, zomwe zimafotokoza chifukwa chake kusowa kwa choline kumawonjezera chiopsezo cha matenda amafuta a chiwindi. PC ikhoza kupezeka kuchokera ku zakudya kapena zowonjezera; Komabe, PC ya phospholipids ndi lipoproteins sichimapezedwa mwachindunji kuchokera ku PC yolowetsedwa kapena yopangidwa kale. Amapangidwa kuchokera ku zoyambira zosiyanasiyana za choline (kuphatikiza GPC), kotero kulowetsa PC sikuyenera kukhala njira yabwino kwambiri yowonjezerera dziwe la PC la thupi.
Kuthandizira kuyenda kwa umuna

• GPC ndi chinthu chofunikira kwambiri pakuphatikizidwa kwa DHA (docosahexaenoic acid), kupanga PC-DHA. DHA-PC complex imagwiritsidwa ntchito m'ma cell omwe amagwira ntchito kwambiri monga ma cell a retina ozindikira kuwala ndi ma cell a umuna. DHA-PC imawonjezera kutulutsa kwa membrane, komwe ndikofunikira kuti umuna ugwire bwino ntchito. Umuna uli ndi kuchuluka kwa GPC; Ma cell a epididymal omwe amakulitsa ma cell a umuna amachotsedwa padziwe la GPC ndikupanga PC-DHA. Kutsika kwa GPC ndi PC-DHA mu umuna kungapangitse chiopsezo cha kuchepa kwa umuna.

Kuyerekeza kwa GPC ndi Acetyl-L-Carnitine (ALCAR)

• Pakufufuza kwa odwala omwe ali ndi matenda a Alzheimer's apamwamba, GPC inachititsa kuti pakhale kusintha kwakukulu mu magawo ambiri a neuropsychological poyerekeza ndi ALCAR. Ngakhale kuti mankhwala onsewa amathandizira kuwonjezeka kwa acetylcholine, n'zotheka kuti pangakhale mgwirizano wogwirizana pakati pa kuphatikizira mankhwala awiriwa, monga GPC imapereka choline pamene ALCAR imapereka gawo la acetyl kuti likhale ndi kaphatikizidwe ka acetylcholine.

Kuthekera kwa mgwirizano pakati pa GPC ndi mankhwala. GPC supplementation sichiganiziridwa kuti imasokoneza molakwika mankhwala aliwonse opangidwa kuti apititse patsogolo ntchito za ubongo. M'malo mwake, chifukwa cha zopindulitsa zake panjira za cholinergic ndikuwongolera magwiridwe antchito a neuronal cell, zitha kukulitsa phindu lawo. GPC ikhoza kupititsa patsogolo zotsatira za acetylcholinesterase AChE inhibitors chifukwa ikhoza kuonjezera kuchuluka kwa ACh mu synaptic cleft, pamene mankhwalawa amachepetsa kuwonongeka kwake.

Kuonjezera apo, malinga ndi maphunziro a zinyama, GPC ikhoza kupititsa patsogolo kupanga dopamine, serotonin, kapena GABA mu ubongo, ndipo GPC ikhoza kupititsa patsogolo zotsatira za reuptake inhibitors za neurotransmitters.

Suzhou Myland Pharm & Nutrition Inc.ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba komanso woyeretsedwa wa Alpha GPC.

Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Ufa wathu wa Alpha GPC umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kukulitsa thanzi labwino, ufa wathu wa Alpha GPC ndiye chisankho chabwino kwambiri.

Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.

Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.