M'dziko lomwe likukula lathanzi komanso thanzi, oleoylethanolamide (OEA) yakhala chowonjezera chodziwika bwino chomwe chimadziwika chifukwa cha zopindulitsa zake pakuwongolera kulemera, kuwongolera chikhumbo, komanso thanzi lathunthu la metabolism. Kufunika kwa zinthu zopangira ufa wa oleoylethanolamide kwachulukirachulukira pomwe anthu ambiri akudziwa zabwino zake. Komabe, kupeza OEA yapamwamba kungakhale ntchito yovuta chifukwa cha kuchuluka kwa zosankha zomwe zilipo.
Podziwa zomwe muyenera kuyang'ana komanso komwe mungagule, mutha kupanga zisankho zolondola zomwe zimagwirizana ndi zolinga zanu zaumoyo. Posankha oleoylethanolamide, nthawi zonse muziika patsogolo chiyero, khalidwe ndi kumveka bwino. Ndi njira iyi yokha yomwe mungasankhe oleoylethanolamide powder mankhwala omwe amakwaniritsa zosowa zanu.
Oleoylethanolamide (OEA),kapena oleoylethanolamide, ndi lipid yochitika mwachilengedwe yomwe imapangidwa m'thupi, makamaka m'matumbo aang'ono. Amachokera ku enzymatic reaction ya oleic acid (monounsaturated fatty acid yomwe imapezeka m'mafuta osiyanasiyana a zakudya) ndi ethanolamine, yomwe ndi yachiwiri ya amide yomwe imakhala ndi lipophilic oleic acid ndi hydrophilic ethanolamine.
OEA ndi molekyulu ya lipid yomwe imapezeka mwachilengedwe muzinthu zina zanyama ndi zomera. Zimapezeka kwambiri mu nyama ndi zomera monga ufa wa cocoa, soya, ndi mtedza, koma zomwe zilimo ndizochepa kwambiri. Pokhapokha pamene chilengedwe chakunja chikusintha kapena chakudya chikalimbikitsidwa, minyewa ya maselo amthupi Izi zimapangidwa mochulukira, kotero OEA itha kugwiritsidwanso ntchito ngati chowonjezera chazakudya.
OEA ndi molekyulu ya amphiphilic yomwe nthawi zambiri imagwiritsidwa ntchito ngati surfactant ndi detergent mumakampani opanga mankhwala. Komabe, kafukufuku wowonjezera adapeza kuti OEA imatha kukhala ngati molekyu yowonetsa lipid mum'matumbo-muubongo ndikuwonetsa zinthu zingapo zamoyo m'thupi, kuphatikiza: kuwongolera chilakolako, kukonza kagayidwe ka lipid, kukulitsa kukumbukira ndi kuzindikira ndi ntchito zina. Mwa iwo, ntchito za OEA zowongolera chikhumbo komanso kukonza kagayidwe ka lipid zalandira chidwi kwambiri.
Oleoylethanolamide (OEA) ndi amkati lipid siginecha molekyulu ndipo ndi ethanolamine gulu la mankhwala. Zimagwira ntchito kwambiri m'thupi mwa kuwongolera njira monga njala, kagayidwe kachakudya ndi mafuta acid oxidation. OEA imapangidwa makamaka m'matumbo aang'ono ndipo imakhudza dongosolo lamanjenje ndi kagayidwe kachakudya pomangirira ku zolandilira zinazake.
Oleylethanolamide imagwira ntchito m'njira zingapo:
● PPAR-α activation: OEA imamangiriza ndi kuyambitsa PPAR-α, cholandilira nyukiliya chomwe chimakhudzidwa ndi kagayidwe ka lipid, kuthandiza kuchepetsa kudya ndi kuonjezera ndalama zogwiritsira ntchito mphamvu.
● Kulimbikitsa lipid oxidation: Poyambitsa PPAR-α, OEA ikhoza kupititsa patsogolo kuwonongeka kwa mafuta acids m'chiwindi ndikulimbikitsa kugwiritsa ntchito mphamvu.
● Kuwongolera mayendedwe a m'matumbo a ubongo: OEA imakhudza zizindikiro za kukhuta mwa kusokoneza mitsempha ya vagus, yomwe imanyamula mauthenga pakati pa matumbo ndi ubongo.
ECS (Endocannabinoid System) ndi njira yovuta yowonetsera ma cell yomwe imaphatikizapo endocannabinoids (monga cannabinoids), zolandilira zawo (CB1 ndi CB2), ndi ma enzyme okhudzana ndi kaphatikizidwe ndi kuwonongeka. ECS imagwira ntchito yofunika kwambiri pakuwongolera njira zosiyanasiyana za thupi, kuphatikizapo chilakolako, kumva ululu, maganizo, kukumbukira, ndi mayankho a chitetezo cha mthupi.
Njira yomwe ECS imakhudzira zochitika zakuthupi ndi izi:
Kuwongolera chitukuko cha neuronal ndi synaptic plasticity: ECS imagwira ntchito yofunika kwambiri pakukula ndi kukula kwa maselo a mitsempha, kuphatikizapo njira monga neurogenesis, glia formation, neuronal migration, synaptogenesis, ndi kudulira kwa synaptic. CB1R ndi AEA zimagwira ntchito zofunika kwambiri pakukula kwaumunthu ndipo zimagwirizanitsidwa ndi kusiyana kwa ma cell ndi kutalika kwa axonal mu dongosolo lapakati lamanjenje.
Amachepetsa ululu ndi mphotho: Cannabinoids amachepetsa ululu pochita zinthu zambiri ndipo awonetsedwa kuti athetse mitundu yosiyanasiyana ya ululu. ECS ndiyofunikiranso ku zotsatira zopindulitsa za zinthu zosokoneza bongo, zomwe zimalimbikitsa zokonda ndikuyambiranso machitidwe azinthu zosiyanasiyana zosokoneza bongo.
Imawongolera magwiridwe antchito ndi kukumbukira: ECS imakhudzidwa pakuwongolera nkhawa ndipo imakhudza kuphunzira, kusunga, kukumbukira ndi kuzindikira njira zamitundu yosiyanasiyana ya kukumbukira. CB1R imagwira ntchito m'malo angapo aubongo ndipo imakhala ndi zotsatira zowongolera pamalingaliro ndi kukumbukira.
Imayang'anira chitetezo cha mthupi ndi ntchito zina: ECS imapezeka m'maselo a chitetezo cha mthupi ndipo imatha kukhudza ntchito zawo. AEA imatha kuletsa kutulutsidwa kwa ma cytokines oyambitsa kutupa ndikuwongolera chitetezo chamthupi. Kuphatikiza apo, ECS imakhudzidwanso pakuwongolera chikhumbo cha kudya, kudya, ndi zochitika zakuthupi zamagulu angapo.
Ubale pakati pa oleoylethanolamine ndi ECS umawonekera makamaka pazinthu izi:
Kuyanjana: OEA imatha kukhudza chikhumbo komanso mphamvu zamagetsi polumikizana ndi zolandilira mu ECS. OEA imaganiziridwa kuti imachepetsa chilakolako cha chakudya ndikulimbikitsa kutsekemera kwa mafuta acids.
Njira yoyendetsera: OEA ingakhudze ntchito ya ECS poyang'anira kaphatikizidwe ndi kuwonongeka kwa endocannabinoids, motero kuchita nawo gawo mu mphamvu ya metabolism ndi kulamulira chilakolako.
Udindo womwe ungachitike: Chifukwa cha gawo lawo pakuwongolera kagayidwe kachakudya ndi chilakolako, ofufuza akuwunika zomwe angathe kuchita pa kunenepa kwambiri, metabolic syndrome, ndi matenda ena okhudzana nawo.
Ponseponse, kuyanjana pakati pa oleoylethanolamine ndi dongosolo la endocannabinoid ndi gawo lochita kafukufuku ndipo lingapereke chidziwitso chatsopano pakumvetsetsa ndi kuchiza matenda okhudzana ndi metabolism.
1. Kuchepetsa chilakolako cha kudya ndi kuchepetsa thupi
OEA ndiyofunikira kwambiri yoletsa kudya, ndipo ntchito yake yayikulu ndikuchepetsa kunenepa kwambiri. Jekeseni wa intraperitoneal wa OEA amatha kuchepetsa kudya komanso kulemera kwa makoswe. Kuwongolera pakamwa kwa OEA kumatha kukhalanso ndi zotsatira zofanana, koma jakisoni wa intracerebroventricular wa OEA satero. Simasokoneza kudya kwa makoswe. Chofunikira chachikulu pakuchepetsa thupi kwa OEA ndikuti imatha kupangitsa kuti munthu azikhuta, potero amaletsa kudya kwambiri. Kuonjezera kuchuluka kwa OEA ku chakudya cha mbewa zabwinobwino kapena onenepa kumachepetsa chilakolako cha mbewa ndi kulemera kwake.
OEA sikuti imalepheretsa kuyamwa kwamafuta m'matumbo, komanso imathandizira kuti beta oxidation yamafuta acids polimbikitsa hydrolysis ya triglycerides mu zotumphukira minofu (chiwindi ndi mafuta), potsirizira pake amachepetsa kudzikundikira kwa mafuta ndikukwaniritsa kulemera.
2. Kuchepetsa lipids m'magazi ndikukana matenda a atherosclerosis
Peroxisome proliferator-activated receptor-α (PPAR-α) ndi mtundu wa cholandirira chogwirizana kwambiri ndi ntchito za metabolic m'thupi. PPAR-α imatenga nawo gawo mu metabolism ya lipid pomanga ku peroxisome proliferator reaction element. Kuyendera kwa metabolic, kuwongolera chitetezo chamthupi, anti-kutupa, anti-proliferation ndi njira zina zofananira nazo zimathandizira pakuwongolera lipids m'magazi ndi anti-atherosclerosis.
OEA ndi analogue ya endocannabinoid yomwe imapangidwa pamene minyewa yamthupi imakokedwa. Kafukufuku wasonyeza kuti OEA imayendetsa PPAR-M, imachepetsa kutulutsidwa kwa endothelin-1, imalepheretsa vasoconstriction ndi kuchuluka kwa maselo osalala a minofu, imalimbikitsa vasodilation, ndipo nthawi yomweyo imawonjezera kaphatikizidwe ka endothelial nitric oxide synthase ndipo imapangitsa kupanga nitric oxide. synthase. nayitrogeni, potero amachepetsa kupanga ma vascular cell adhesion molecules, kukwaniritsa zotsatira zotsutsana ndi kutupa, ndikukhala ndi zotsatira zochepetsera magazi lipids ndi anti-atherosclerosis.
3. Kuwongolera bulimia
Vuto la kudya mopambanitsa (BED) ndilo vuto lofala kwambiri la kadyedwe, lomwe limadziwika ndi kudya mopitirira muyeso, mokakamiza, komwe kumatsagana ndi kulephera kudziletsa, manyazi, kudziimba mlandu, kunyansidwa, ndi nkhawa.
Ngakhale kuti zinthu zomwe zimayambitsa kudya kwambiri sizikudziwikabe, pali umboni wosonyeza kuti kudya kwambiri komanso kupsinjika maganizo ndizomwe zimayambitsa kudya kwambiri. Kafukufuku wina wasonyeza kuti njira za neurobiological za kudya mopambanitsa zimayang'ana pa kuyambitsa kwa mesocortical limbic dopamine (DA) system ndi brain serotonin (5-HT) ndi norepinephrine (NA) signing.
Oleylethanolamide (OEA) ndi lipid metabolite yomwe imapezeka mwachilengedwe yomwe imagwira ntchito yofunika kwambiri pakuwongolera chilakolako, kuwongolera mphamvu, komanso kasamalidwe ka kulemera. Monga chowongolera chofunikira cha thupi, OEA imalumikizana ndi peroxisome proliferator-activated receptor α (PPAR-α) kuti ilimbikitse kukhuta komanso kupangitsa kuti mafuta azikhala oxidation. Ochita kafukufuku akhala akuyang'ana mphamvu zochiritsira za OEA, zomwe zimapangitsa kuti pakhale chitukuko cha oleoylethanolamide zowonjezera zomwe zimapangidwira kuthandizira ntchitoyi.
MusanaguleOleylethanolamide (OEA) ufa, ganizirani izi:
1. Kumvetsetsa OEA
Zomwe zili: OEA ndi ethanolamide yamafuta acid yomwe imathandizira kuwongolera chilakolako cha chakudya, metabolism, ndi homeostasis yamphamvu. Zimathandizira kuchepetsa thupi, kusintha kagayidwe ka lipid, ndikuwonjezera kugwiritsa ntchito mphamvu.
2. Ubwino ndi Chiyero
Gwero: Gulani kuchokera kwa ogulitsa odalirika omwe amapereka mayeso a chipani chachitatu kuti akhale oyera ndi abwino.
Certificate of Analysis (CoA): Imawonetsetsa kuti malonda ali ndi CoA yotsimikizira kapangidwe kake komanso kusakhalapo kwa zoipitsa.
3. Mlingo ndi kagwiritsidwe ntchito
Mlingo wovomerezeka: Kafukufuku adalimbikitsa mlingo ndikufunsana ndi katswiri wazachipatala kuti akupatseni malingaliro anu.
Mafomu Odyera: OEA imabwera m'njira zosiyanasiyana (ufa, kapisozi). Sankhani chinthu chomwe chikugwirizana ndi moyo wanu.
4. Zotsatira zoyipa zomwe zingachitike
Zotsatira Zina: Ngakhale kuti nthawi zambiri zimawonedwa ngati zotetezeka, ena ogwiritsa ntchito amatha kumva kusapeza bwino kwa m'mimba kapena zotsatira zina zazing'ono.
Funsani dokotala wanu: Ngati muli ndi matenda omwe analipo kale kapena mukumwa mankhwala, funsani dokotala musanagwiritse ntchito.
5. Udindo walamulo
Malamulo: Yang'anani momwe malamulo a OEA alili m'dziko lanu chifukwa malamulo angasiyane.
6. Kusungirako ndi moyo wa alumali
Zosungirako Zosungirako: Onetsetsani kuti mukumvetsa momwe mungasungire bwino ufa kuti ukhale wogwira mtima.
Tsiku lotha ntchito: Onani tsiku lotha ntchito kuti muwonetsetse kuti mukugula zatsopano.
7. Mtengo ndi mtengo
Kuyerekeza Mtengo: Fananizani mitengo kuchokera kwa ogulitsa osiyanasiyana, koma samalani ndi mitengo yotsika kwambiri yomwe ingasonyeze kutsika.
Gulani zambiri: Ngati mukufuna kuzigwiritsa ntchito kwa nthawi yayitali, ganizirani kugula zambiri chifukwa zingachepetse ndalama.
8. Phatikizani ndi zowonjezera zina
Zotsatira za Synergistic: Fufuzani momwe OEA imagwirira ntchito ndi zowonjezera zina kapena kusintha kwazakudya komwe mungaganizire.
Poganizira izi, mukhoza kupanga chisankho chodziwika bwino pogula oleoylethanolamide ufa. Nthawi zonse muziika patsogolo chitetezo ndi khalidwe posankha chowonjezera.
Anapita masiku oti simumadziwa komwe mungagule ufa wa oleylethanolamine. Masiku ano, pali malo ambiri omwe mungagule magnesium acetyl taurate powder. Chifukwa cha intaneti, mutha kugula chilichonse osasiya ngakhale nyumba yanu. Kukhala pa intaneti sikumangopangitsa ntchito yanu kukhala yosavuta, kumapangitsanso kuti muzitha kugula zinthu mosavuta. Mulinso ndi mwayi wowerenga zambiri za oleoylethanolamine zodabwitsazi musanasankhe kugula.
Suzhou Myland Pharm & Nutrition Inc. ndi wopanga olembetsedwa ndi FDA yemwe amapereka ufa wapamwamba kwambiri komanso woyeretsedwa kwambiri wa Oleoylethanolamide (OEA).
Ku Suzhou Myland Pharm tadzipereka kupereka zinthu zapamwamba kwambiri pamitengo yabwino kwambiri. Oleoylethanolamide (OEA) ufa wathu umayesedwa mwamphamvu kuti ukhale woyera ndi potency, kuonetsetsa kuti mumapeza chowonjezera chapamwamba chomwe mungakhulupirire. Kaya mukufuna kuthandizira thanzi la ma cell, kulimbikitsa chitetezo chamthupi kapena kukulitsa thanzi labwino, Oleoylethanolamide (OEA) ufa wathu ndiye chisankho chabwino kwambiri.
Ndi zaka 30 zachidziwitso komanso motsogozedwa ndiukadaulo wapamwamba komanso njira zokongoletsedwa bwino za R&D, Suzhou Myland Pharm yapanga zinthu zambiri zampikisano ndikukhala kampani yotsogola ya sayansi ya moyo, kaphatikizidwe kazinthu ndi ntchito zopanga.
Kuphatikiza apo, Suzhou Myland Pharm ndiwopanganso zolembedwa ndi FDA. Zothandizira zamakampani za R&D, malo opangira zinthu, ndi zida zowunikira ndi zamakono komanso zogwira ntchito zambiri, ndipo zimatha kupanga mankhwala kuchokera ku ma milligrams mpaka matani mumlingo, ndikutsata miyezo ya ISO 9001 ndi zopangira GMP.
Q: Kodi Oleoylethanolamide (OEA) ndi chiyani ndipo ubwino wake ndi wotani?
A: Oleoylethanolamide (OEA) ndi lipid yochitika mwachilengedwe yomwe imagwira ntchito pakuwongolera chilakolako, kagayidwe, komanso mphamvu. Nthawi zambiri amagwiritsidwa ntchito ngati chowonjezera chazakudya pakuwongolera kulemera, kulimbikitsa kukhuta, komanso kukulitsa kagayidwe ka mafuta.
Q: Kodi ndimadziwa bwanji ubwino wa Oleoylethanolamide powder?
A: Kuti mudziwe ubwino wa ufa wa Oleoylethanolamide, yang'anani mankhwala omwe amapereka Certificate of Analysis (COA) kuchokera ku labu lachitatu. Kuphatikiza apo, yang'anani kuwunika kwamakasitomala, kuwonekera kwazinthu, komanso ngati malondawo alibe zowononga ndi zodzaza.
Q: Ndiyenera kuganizira chiyani ndikagula Oleoylethanolamide powder?
A: Mukamagula ufa wa Oleoylethanolamide, ganizirani zinthu monga gwero la mankhwala, kuchuluka kwa OEA, kupezeka kwa zowonjezera zilizonse, mbiri ya wopanga, ndi ndemanga za makasitomala. Ndikofunikiranso kuyang'ana momwe mungasungire moyenera komanso malangizo oyendetsera.
Chodzikanira: Nkhaniyi ndi yachidziwitso chokhacho ndipo siyenera kuwonedwa ngati upangiri wachipatala. Zina mwazolemba zamabulogu zimachokera pa intaneti ndipo sizodziwika. Webusaitiyi ili ndi udindo wokonza, kusanja ndi kusintha zolemba. Cholinga chopereka zambiri sikutanthauza kuti mukugwirizana ndi maganizo ake kapena kutsimikizira kuti zomwe zili m'nkhaniyi ndi zoona. Nthawi zonse funsani dokotala musanagwiritse ntchito zowonjezera zowonjezera kapena kusintha ndondomeko yanu yachipatala.
Nthawi yotumiza: Sep-27-2024
